Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1108434..1108959 Replicon chromosome
Accession NZ_CP007064
Organism Fusobacterium nucleatum subsp. vincentii 3_1_27

Toxin (Protein)


Gene name relE Uniprot ID A0A806UQ73
Locus tag HMPREF0405_RS05300 Protein ID WP_008797335.1
Coordinates 1108434..1108706 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A806UI43
Locus tag HMPREF0405_RS05305 Protein ID WP_020789402.1
Coordinates 1108699..1108959 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0405_RS05275 1103892..1104434 - 543 WP_025374933.1 5-formyltetrahydrofolate cyclo-ligase -
HMPREF0405_RS05280 1104427..1105014 - 588 WP_008797331.1 uracil-DNA glycosylase -
HMPREF0405_RS05285 1105024..1105806 - 783 WP_008797332.1 MBL fold metallo-hydrolase -
HMPREF0405_RS05290 1105813..1106529 - 717 WP_008797333.1 SDR family NAD(P)-dependent oxidoreductase -
HMPREF0405_RS05295 1106538..1108409 - 1872 WP_008797334.1 radical SAM protein -
HMPREF0405_RS05300 1108434..1108706 - 273 WP_008797335.1 type II toxin-antitoxin system YafQ family toxin Toxin
HMPREF0405_RS05305 1108699..1108959 - 261 WP_020789402.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HMPREF0405_RS05310 1109206..1109493 - 288 Protein_1027 MmcQ/YjbR family DNA-binding protein -
HMPREF0405_RS05315 1109596..1110903 + 1308 WP_008797337.1 hypothetical protein -
HMPREF0405_RS05320 1110896..1112479 + 1584 WP_025374934.1 hypothetical protein -
HMPREF0405_RS05325 1112572..1113119 - 548 Protein_1030 YcxB family protein -
HMPREF0405_RS05330 1113150..1113572 - 423 WP_005888030.1 Rrf2 family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10759.60 Da        Isoelectric Point: 9.3533

>T46022 WP_008797335.1 NZ_CP007064:c1108706-1108434 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
MLKIKYHTKFKKDYKLIIKRGYNLKLLEEIIDNLANEKTLLPKNKDHSLTGNYEGFRECHITPDWLLIYRIEENNLILVL
LRTGTHSDLF

Download         Length: 273 bp

>T46022 NZ_CP007064:c1108706-1108434 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
ATGCTTAAAATCAAATATCACACTAAATTTAAAAAAGACTATAAACTTATAATAAAAAGAGGTTACAATTTAAAATTATT
AGAAGAAATTATTGATAATTTGGCAAATGAAAAGACTTTATTACCTAAAAATAAAGATCATAGTTTAACTGGAAATTATG
AAGGATTTAGAGAATGTCATATAACTCCTGATTGGCTATTAATTTATAGAATAGAAGAAAATAATCTTATATTAGTTTTA
TTGAGAACAGGAACTCATTCTGATTTATTTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9820.30 Da        Isoelectric Point: 4.8408

>AT46022 WP_020789402.1 NZ_CP007064:c1108959-1108699 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
MAQVSVTVKTDEEIKKDFNTFCEEIGLNMSTAINLFMRAVLREKRIPFELSLSNNETIQVFKDVKEGKNLSKSFSSVKEL
MEDLNA

Download         Length: 261 bp

>AT46022 NZ_CP007064:c1108959-1108699 [Fusobacterium nucleatum subsp. vincentii 3_1_27]
ATGGCACAAGTTAGTGTAACAGTAAAAACGGATGAAGAAATAAAAAAAGATTTTAATACTTTTTGTGAAGAAATTGGTTT
AAATATGTCAACTGCTATAAATTTATTTATGAGAGCTGTTTTAAGAGAAAAAAGAATTCCTTTTGAACTTAGCTTATCTA
ATAATGAAACTATACAAGTTTTTAAAGATGTAAAAGAAGGCAAAAATTTAAGTAAGTCATTTAGTTCTGTTAAAGAATTA
ATGGAGGACTTAAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806UQ73

Antitoxin

Source ID Structure
AlphaFold DB A0A806UI43

References