Detailed information of TA system TA046021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2260833..2261344
• Replicon: chromosome
• Accession: NZ_CP007062
• Organism: Fusobacterium nucleatum subsp. animalis 7_1

Toxin (Protein)

• Gene name: relB
• Uniprot ID: F7L0U8
• Locus tag: FSDG_RS10835
• Protein ID: WP_005910516.1
• Coordinates: 2260833..2261087 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F7L0U9
• Locus tag: FSDG_RS10840
• Protein ID: WP_005910514.1
• Coordinates: 2261087..2261344 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSDG_RS10815	2256562..2257878	-	1317	WP_005905476.1	electron transport complex subunit RsxC	-
FSDG_RS10820	2257952..2258527	-	576	WP_005910552.1	aminoacyl-tRNA hydrolase	-
FSDG_RS10825	2258667..2259404	-	738	WP_008701810.1	tRNA pseudouridine(38-40) synthase TruA	-
FSDG_RS10830	2259636..2260712	-	1077	WP_008701808.1	DHH family phosphoesterase	-
FSDG_RS10835	2260833..2261087	-	255	WP_005910516.1	Txe/YoeB family addiction module toxin	Toxin
FSDG_RS10840	2261087..2261344	-	258	WP_005910514.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FSDG_RS10845	2261464..2262537	-	1074	WP_005910513.1	glycerophosphodiester phosphodiesterase	-
FSDG_RS10850	2262576..2263574	-	999	WP_008701806.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
FSDG_RS10855	2263602..2264075	-	474	WP_008701805.1	OmpH family outer membrane protein	-
FSDG_RS10860	2264116..2266209	-	2094	WP_005910510.1	outer membrane protein assembly factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2205947..2343109	137162

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10007.42 Da
• Isoelectric Point: 8.0154

>T46021 WP_005910516.1 NZ_CP007062:c2261087-2260833 [Fusobacterium nucleatum subsp. animalis 7_1]
MLLTWTDFAWEQYEELQEKDKRLVKKINTLIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQITIVAC
ANHY

Nucleotide

• Length: 255 bp

>T46021 NZ_CP007062:c2261087-2260833 [Fusobacterium nucleatum subsp. animalis 7_1]
ATGTTATTGACTTGGACTGATTTTGCTTGGGAACAATATGAAGAATTACAAGAAAAAGATAAAAGACTTGTAAAAAAGAT
AAATACACTTATTAAGGATATCAAAAGAAATGGTAATGAAGGAATAGGAAAACCAGAACCTTTACAACATGAACTAAGTG
GTTATTGGAGTAGAAGAATTGATGATAAAAATAGATTAGTTTATAAAATATCAGATACTCAAATAACAATAGTTGCTTGT
GCAAATCATTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10140.41 Da
• Isoelectric Point: 4.7022

>AT46021 WP_005910514.1 NZ_CP007062:c2261344-2261087 [Fusobacterium nucleatum subsp. animalis 7_1]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEAEKGNVKEHD
LIEVD

Nucleotide

• Length: 258 bp

>AT46021 NZ_CP007062:c2261344-2261087 [Fusobacterium nucleatum subsp. animalis 7_1]
ATGATAGCAACAAATTATTCAGAGGTTAGAAATAATTTAAAAACTTATTGTGATAAGGCAACAAAGGACTATGAAACTAT
AATTATTACAAGAAAAAATAATGAAAATGTTGTTTTAATGAGTGAAGAAGAATATAACAATCTTATGGAAAACCTTTATA
TAAGATCAAATCTTAAATATTATCAAAGACTTGTAGAAAGTATAAAAGAAGCTGAAAAGGGTAATGTTAAAGAACATGAT
TTAATAGAGGTGGATTAA

Structures

Toxin

• AlphaFold DB: F7L0U8

Antitoxin

• AlphaFold DB: F7L0U9