Detailed information of TA system TA046003

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2351821..2352501
• Replicon: chromosome
• Accession: NZ_CP007044
• Organism: Chania multitudinisentens RB-25

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: W0LAW4
• Locus tag: Z042_RS10350
• Protein ID: WP_024914336.1
• Coordinates: 2351821..2352141 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: W0L9Q7
• Locus tag: Z042_RS10355
• Protein ID: WP_024914335.1
• Coordinates: 2352178..2352501 (-)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Z042_RS10330	2346976..2347302	-	327	WP_024914514.1	DUF1493 family protein	-
Z042_RS10335	2347296..2347742	-	447	Protein_2038	hypothetical protein	-
Z042_RS25965	2348196..2348354	+	159	WP_154666939.1	hypothetical protein	-
Z042_RS10340	2348596..2349636	-	1041	WP_024914326.1	IS481 family transposase	-
Z042_RS10345	2349816..2350745	-	930	WP_024914337.1	tetratricopeptide repeat protein	-
Z042_RS24975	2350865..2351128	-	264	Protein_2042	diaminopimelate epimerase	-
Z042_RS10350	2351821..2352141	-	321	WP_024914336.1	TA system toxin CbtA family protein	Toxin
Z042_RS10355	2352178..2352501	-	324	WP_024914335.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
Z042_RS10360	2352514..2352990	-	477	WP_024914334.1	hypothetical protein	-
Z042_RS10365	2353061..2353882	-	822	WP_024914333.1	DUF945 domain-containing protein	-
Z042_RS10370	2354004..2354465	-	462	WP_037407592.1	hypothetical protein	-
Z042_RS10375	2354586..2355206	-	621	WP_024914331.1	hypothetical protein	-
Z042_RS10380	2355212..2355913	-	702	WP_024914330.1	transcriptional regulator	-
Z042_RS10385	2356126..2357001	-	876	WP_024914329.1	GTPase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2342286..2376141	33855

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-105)

Antitoxin

• Antitoxin CbeA (7-107)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11970.59 Da
• Isoelectric Point: 6.3209

>T46003 WP_024914336.1 NZ_CP007044:c2352141-2351821 [Chania multitudinisentens RB-25]
MHISSVPATVPVASRLSPVQVWQQLLTYLLDHHYGLTLNDTPFHNDAAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLLST

Nucleotide

• Length: 321 bp

>T46003 NZ_CP007044:c2352141-2351821 [Chania multitudinisentens RB-25]
ATGCACATTTCATCTGTACCGGCCACGGTGCCGGTTGCGTCACGCTTGTCGCCCGTACAGGTCTGGCAGCAACTTTTAAC
GTATCTGCTGGATCACCATTACGGCCTGACGCTTAACGACACGCCATTCCACAACGACGCGGCCATTCAGGAACATATTG
AAGCAGGAATAACGCTTGCTGATGCGGTAAATTTCCTGGTGGAACGCTATGAACTGGTTCGCACTGACCGCAAAGGGTTT
ACATGGCAGGAGCAGACACCATTTCTGACCGCGACCGATATTCTCAGAGCCAGACGAGCTACCGGGCTGTTGAGCACTTA
A

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12049.65 Da
• Isoelectric Point: 5.4431

>AT46003 WP_024914335.1 NZ_CP007044:c2352501-2352178 [Chania multitudinisentens RB-25]
MPLTPPHEWGLQSDITPRFGTRLVQEGNRLHYLADRAGLTGSFSPEQLQKLDQAFPLFIDLLEEMLHSGELNPHQQHQVT
IQLASLTCIADTRGSCGYVYISIYPTQ

Nucleotide

• Length: 324 bp

>AT46003 NZ_CP007044:c2352501-2352178 [Chania multitudinisentens RB-25]
ATGCCATTAACACCACCTCATGAATGGGGGTTACAAAGTGATATCACCCCACGATTTGGCACAAGATTGGTTCAGGAAGG
TAACCGGCTGCATTACCTGGCTGACAGGGCTGGGTTGACGGGGAGCTTTAGCCCGGAGCAATTACAGAAACTGGATCAGG
CTTTCCCGCTGTTTATAGATCTGCTGGAAGAAATGCTGCATTCCGGTGAGCTAAACCCACACCAGCAACATCAGGTGACC
ATTCAGCTTGCGAGTTTAACCTGCATAGCTGATACCCGTGGTAGCTGCGGCTACGTTTACATTTCGATTTATCCAACCCA
GTGA

Structures

Toxin

• AlphaFold DB: W0LAW4

Antitoxin

• AlphaFold DB: W0L9Q7