Detailed information of TA system TA046001

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2092389..2093061
• Replicon: chromosome
• Accession: NZ_CP007044
• Organism: Chania multitudinisentens RB-25

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: W0L688
• Locus tag: Z042_RS09270
• Protein ID: WP_024910038.1
• Coordinates: 2092636..2093061 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W0LAA3
• Locus tag: Z042_RS09265
• Protein ID: WP_024910037.1
• Coordinates: 2092389..2092655 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Z042_RS09240	2087910..2088656	+	747	WP_024910032.1	SDR family oxidoreductase	-
Z042_RS09245	2088848..2089456	-	609	WP_024910033.1	HD domain-containing protein	-
Z042_RS09250	2089644..2090309	+	666	WP_154666929.1	hemolysin III family protein	-
Z042_RS09255	2090477..2090974	+	498	WP_024910035.1	DUF2165 domain-containing protein	-
Z042_RS09260	2091019..2092011	-	993	WP_024910036.1	tRNA-modifying protein YgfZ	-
Z042_RS09265	2092389..2092655	+	267	WP_024910037.1	FAD assembly factor SdhE	Antitoxin
Z042_RS09270	2092636..2093061	+	426	WP_024910038.1	protein YgfX	Toxin
Z042_RS09275	2093058..2093753	+	696	WP_024910039.1	two-component system response regulator CreB	-
Z042_RS09280	2093750..2095168	+	1419	WP_024910040.1	two-component system sensor histidine kinase CreC	-
Z042_RS09285	2095253..2096677	+	1425	WP_024910041.1	cell envelope integrity protein CreD	-
Z042_RS09290	2096712..2097230	-	519	WP_024910042.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16615.67 Da
• Isoelectric Point: 10.9319

>T46001 WP_024910038.1 NZ_CP007044:2092636-2093061 [Chania multitudinisentens RB-25]
VAQWRCDVRISWRTQLISLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLAERRVEWRNQ
EWLMLKQPWMIGMGILLTLQQVNGKKRCRLWLASDCLSKAEWRHLRQLLRYSPSNENGNAS

Nucleotide

• Length: 426 bp

>T46001 NZ_CP007044:2092636-2093061 [Chania multitudinisentens RB-25]
GTGGCCCAGTGGCGTTGTGATGTCCGCATTTCCTGGCGAACCCAGTTAATCTCGTTGTTGACCCATGGTGTACTGATATT
ACTGATCCTGATTTCACCTTGGCCGGAAGGTTATGGGCCTATTTGGTTGGTTTTGTTGACGCTGGTGGTTTTTGAATGCA
TTCGTAGCCAGAAGCGCATCGCATCAAGGCAGGGAGAGTTGCGGTTGCTGGCGGAACGGCGGGTGGAGTGGCGTAACCAG
GAATGGTTGATGTTGAAACAGCCCTGGATGATAGGGATGGGCATTTTGCTGACGTTGCAGCAGGTTAACGGCAAAAAACG
CTGTAGATTATGGCTGGCTTCCGATTGCCTGAGCAAAGCGGAATGGCGTCATCTACGCCAGTTGCTGCGGTATTCCCCCT
CTAACGAAAACGGAAATGCATCATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10371.85 Da
• Isoelectric Point: 5.6062

>AT46001 WP_024910037.1 NZ_CP007044:2092389-2092655 [Chania multitudinisentens RB-25]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDEDKALFIRLLASDDPDLFNWLMNHGAPQDKELQRMVSLIQTRN
KDRGPVAL

Nucleotide

• Length: 267 bp

>AT46001 NZ_CP007044:2092389-2092655 [Chania multitudinisentens RB-25]
ATGGATATTAATAACAAAGCCCGTATTCACTGGGCCTGCCGCCGAGGAATGCGTGAGTTGGATATTTCGATCATGCCGTT
TTTTGAGCATGAGTACGATACGTTGAGTGACGAAGACAAGGCGCTGTTTATCCGTTTGCTTGCAAGTGATGATCCCGACT
TGTTCAACTGGCTGATGAATCATGGTGCTCCGCAGGACAAAGAATTGCAGAGAATGGTTTCCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGTTGTGA

Structures

Toxin

• AlphaFold DB: W0L688

Antitoxin

• AlphaFold DB: W0LAA3