Detailed information of TA system TA045999

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 892048..892949
• Replicon: chromosome
• Accession: NZ_CP007044
• Organism: Chania multitudinisentens RB-25

Toxin (Protein)

• Gene name: -
• Uniprot ID: W0LEC0
• Locus tag: Z042_RS03850
• Protein ID: WP_024912880.1
• Coordinates: 892491..892949 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: W0L972
• Locus tag: Z042_RS03845
• Protein ID: WP_024912879.1
• Coordinates: 892048..892494 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Z042_RS03825	889040..889612	+	573	WP_024912875.1	DNA-3-methyladenine glycosylase I	-
Z042_RS03830	889648..890055	+	408	WP_024912876.1	N-acetyltransferase	-
Z042_RS03835	890209..890868	+	660	WP_024912877.1	OmpA family lipoprotein	-
Z042_RS03840	890988..891971	+	984	WP_024912878.1	glyoxylate/hydroxypyruvate reductase GhrB	-
Z042_RS03845	892048..892494	+	447	WP_024912879.1	DUF2384 domain-containing protein	Antitoxin
Z042_RS03850	892491..892949	+	459	WP_024912880.1	RES domain-containing protein	Toxin
Z042_RS03855	893083..895149	+	2067	WP_024912881.1	alpha-amylase	-
Z042_RS03860	895336..896589	+	1254	WP_024912882.1	valine--pyruvate transaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (4-137)

Antitoxin

• Antitoxin Xre (15-148)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16825.31 Da
• Isoelectric Point: 5.0700

>T45999 WP_024912880.1 NZ_CP007044:892491-892949 [Chania multitudinisentens RB-25]
VIGYRIVKTKYLATAWSGYGAQQFGGRWNHKGKAMLYLATSVSLAMLECLVHFDDAALLQHYTLLSIDIPDRDIITLEPT
ALPANWQQLAAPQETMDIGSEWLDSETSVGLLVPSAVVPMENNLLINPQHADFTAYLSSVQAIPHLFDARLK

Nucleotide

• Length: 459 bp

>T45999 NZ_CP007044:892491-892949 [Chania multitudinisentens RB-25]
GTGATCGGTTATCGGATCGTGAAAACCAAATACTTGGCTACTGCCTGGTCTGGTTACGGCGCACAGCAATTCGGTGGCCG
CTGGAATCACAAGGGGAAAGCCATGCTCTATCTGGCAACCTCGGTTTCCTTGGCGATGCTCGAATGCCTGGTGCATTTTG
ATGATGCAGCCTTGTTGCAGCATTACACCTTGCTGAGCATCGATATACCCGACAGGGATATTATTACGCTAGAACCTACC
GCATTGCCGGCAAACTGGCAGCAATTGGCAGCCCCACAAGAGACGATGGATATCGGTTCTGAGTGGCTGGACTCTGAAAC
CTCTGTCGGCTTATTGGTTCCTTCAGCGGTGGTGCCGATGGAAAACAACCTCTTGATTAACCCCCAGCACGCGGATTTCA
CGGCCTACCTGAGTAGCGTTCAGGCGATACCGCATCTGTTTGATGCAAGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16138.59 Da
• Isoelectric Point: 10.5450

>AT45999 WP_024912879.1 NZ_CP007044:892048-892494 [Chania multitudinisentens RB-25]
MRTFSPSKGPTNNELWRSAGFPASRGPELILRLRQGLPVSVIETIHSWVGFPKADILRITGINAKTLSRRKAGSGILSPE
ESEKIARLIRVADAAVALFEGDREKAISWLRKPVRGLGNETPESLLNTESGAVEVLELIGKLEHGVFS

Nucleotide

• Length: 447 bp

>AT45999 NZ_CP007044:892048-892494 [Chania multitudinisentens RB-25]
ATGCGCACATTCAGCCCATCGAAAGGGCCAACGAATAACGAACTGTGGCGCTCTGCCGGTTTCCCAGCCAGCAGAGGGCC
TGAGTTAATCCTGCGTCTGCGCCAAGGTTTACCGGTATCGGTTATTGAAACCATACACAGTTGGGTGGGTTTTCCTAAAG
CGGATATCCTGCGCATTACCGGTATCAACGCCAAAACGTTGAGCCGCAGGAAAGCGGGAAGCGGGATATTAAGCCCGGAA
GAAAGCGAGAAGATTGCGCGCTTAATCCGTGTGGCCGATGCAGCAGTCGCGCTCTTTGAAGGCGATCGCGAGAAAGCCAT
TAGCTGGTTGCGTAAGCCAGTTCGTGGTTTGGGCAATGAAACCCCTGAGAGCCTGCTTAACACTGAGAGCGGTGCGGTTG
AGGTGCTCGAGCTCATCGGCAAACTGGAGCACGGCGTCTTCTCGTGA

Structures

Toxin

• AlphaFold DB: W0LEC0

Antitoxin

• AlphaFold DB: W0L972