Detailed information of TA system TA045996

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1666581..1667193
• Replicon: chromosome
• Accession: NZ_CP007041
• Organism: Streptococcus pyogenes STAB902

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A4Z2JY48
• Locus tag: STAB902_RS08605
• Protein ID: WP_002982731.1
• Coordinates: 1666858..1667193 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A5S4TJ53
• Locus tag: STAB902_RS08600
• Protein ID: WP_011055007.1
• Coordinates: 1666581..1666868 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STAB902_RS08575	1661773..1662756	-	984	WP_011055003.1	tagatose-bisphosphate aldolase	-
STAB902_RS08580	1662760..1663689	-	930	WP_011055004.1	tagatose-6-phosphate kinase	-
STAB902_RS08585	1663735..1664250	-	516	WP_011055005.1	galactose-6-phosphate isomerase subunit LacB	-
STAB902_RS08590	1664285..1664713	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
STAB902_RS08595	1665158..1665931	+	774	WP_011055006.1	DeoR/GlpR family DNA-binding transcription regulator	-
STAB902_RS08600	1666581..1666868	+	288	WP_011055007.1	hypothetical protein	Antitoxin
STAB902_RS08605	1666858..1667193	+	336	WP_002982731.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
STAB902_RS10305	1667260..1668331	+	1072	Protein_1652	site-specific integrase	-
STAB902_RS08615	1668463..1668855	-	393	WP_002982716.1	30S ribosomal protein S9	-
STAB902_RS08620	1668876..1669322	-	447	WP_002982710.1	50S ribosomal protein L13	-
STAB902_RS08625	1669540..1669746	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
STAB902_RS08630	1669743..1670441	-	699	WP_011055008.1	hypothetical protein	-
STAB902_RS08635	1670568..1671428	-	861	WP_011055009.1	DegV family protein	-
STAB902_RS08640	1671525..1672043	-	519	WP_011055010.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13145.88 Da
• Isoelectric Point: 5.2144

>T45996 WP_002982731.1 NZ_CP007041:1666858-1667193 [Streptococcus pyogenes STAB902]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T45996 NZ_CP007041:1666858-1667193 [Streptococcus pyogenes STAB902]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10964.59 Da
• Isoelectric Point: 5.2318

>AT45996 WP_011055007.1 NZ_CP007041:1666581-1666868 [Streptococcus pyogenes STAB902]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT45996 NZ_CP007041:1666581-1666868 [Streptococcus pyogenes STAB902]
ATGACTACAGTAAAAAAAAACAGAACGGTTACCTTTCAAGCTAATAAAGAACTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A4Z2JY48

Antitoxin

• AlphaFold DB: A0A5S4TJ53