Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3093909..3094710 | Replicon | chromosome |
| Accession | NZ_CP007037 | ||
| Organism | Shigella flexneri G1663 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | D3GUT5 |
| Locus tag | SF2A_RS16800 | Protein ID | WP_001094430.1 |
| Coordinates | 3094333..3094710 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | SF2A_RS16795 | Protein ID | WP_001285622.1 |
| Coordinates | 3093909..3094286 (+) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SF2A_RS16760 (3090530) | 3090530..3090985 | + | 456 | WP_005051844.1 | IrmA family protein | - |
| SF2A_RS30975 (3091128) | 3091128..3091217 | + | 90 | WP_112031555.1 | DUF905 family protein | - |
| SF2A_RS16770 (3091396) | 3091396..3092214 | + | 819 | WP_001177758.1 | DUF932 domain-containing protein | - |
| SF2A_RS16780 (3092556) | 3092556..3093029 | + | 474 | WP_000855059.1 | antirestriction protein | - |
| SF2A_RS16785 (3093045) | 3093045..3093521 | + | 477 | WP_001387238.1 | RadC family protein | - |
| SF2A_RS16790 (3093608) | 3093608..3093829 | + | 222 | WP_000692350.1 | DUF987 domain-containing protein | - |
| SF2A_RS16795 (3093909) | 3093909..3094286 | + | 378 | WP_001285622.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| SF2A_RS16800 (3094333) | 3094333..3094710 | + | 378 | WP_001094430.1 | TA system toxin CbtA family protein | Toxin |
| SF2A_RS16805 (3094707) | 3094707..3095195 | + | 489 | WP_000761715.1 | DUF5983 family protein | - |
| SF2A_RS16810 (3095215) | 3095215..3095412 | + | 198 | WP_000772029.1 | DUF957 domain-containing protein | - |
| SF2A_RS16815 (3095497) | 3095497..3096339 | + | 843 | WP_001290187.1 | DUF4942 domain-containing protein | - |
| SF2A_RS16820 (3097116) | 3097116..3097361 | + | 246 | WP_000875412.1 | hypothetical protein | - |
| SF2A_RS16830 (3097764) | 3097764..3098926 | + | 1163 | WP_094081514.1 | IS3-like element IS3 family transposase | - |
| SF2A_RS16835 (3099030) | 3099030..3099497 | - | 468 | WP_011069513.1 | prepilin peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sigA / pic | 3035869..3100950 | 65081 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13971.82 Da Isoelectric Point: 6.8608
>T45987 WP_001094430.1 NZ_CP007037:3094333-3094710 [Shigella flexneri G1663]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ
Download Length: 378 bp
>T45987 NZ_CP007037:3094333-3094710 [Shigella flexneri G1663]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGAATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13697.54 Da Isoelectric Point: 6.3127
>AT45987 WP_001285622.1 NZ_CP007037:3093909-3094286 [Shigella flexneri G1663]
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLNQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
VSDTLPGTTPPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDVDAYHLNQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV
Download Length: 378 bp
>AT45987 NZ_CP007037:3093909-3094286 [Shigella flexneri G1663]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGAACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGAACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|