Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2971554..2972208 Replicon chromosome
Accession NZ_CP007037
Organism Shigella flexneri G1663

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag SF2A_RS16175 Protein ID WP_000244767.1
Coordinates 2971554..2971961 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag SF2A_RS16180 Protein ID WP_000354044.1
Coordinates 2971942..2972208 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SF2A_RS16155 (2967511) 2967511..2969244 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
SF2A_RS16160 (2969250) 2969250..2969960 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SF2A_RS16165 (2969985) 2969985..2970881 - 897 WP_000806987.1 site-specific tyrosine recombinase XerD -
SF2A_RS16170 (2970993) 2970993..2971514 + 522 WP_001055867.1 flavodoxin FldB -
SF2A_RS16175 (2971554) 2971554..2971961 - 408 WP_000244767.1 protein YgfX Toxin
SF2A_RS16180 (2971942) 2971942..2972208 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
SF2A_RS16185 (2972451) 2972451..2973431 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
SF2A_RS16190 (2973627) 2973627..2974286 - 660 WP_000250274.1 hemolysin III family protein -
SF2A_RS16195 (2974450) 2974450..2974760 - 311 Protein_2955 N(4)-acetylcytidine aminohydrolase -
SF2A_RS16200 (2974805) 2974805..2976238 + 1434 WP_005051722.1 6-phospho-beta-glucosidase BglA -
SF2A_RS16205 (2976295) 2976295..2977038 - 744 WP_000951957.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T45986 WP_000244767.1 NZ_CP007037:c2971961-2971554 [Shigella flexneri G1663]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T45986 NZ_CP007037:c2971961-2971554 [Shigella flexneri G1663]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT45986 WP_000354044.1 NZ_CP007037:c2972208-2971942 [Shigella flexneri G1663]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT45986 NZ_CP007037:c2972208-2971942 [Shigella flexneri G1663]
ATGGACATTAACAACAAAGCCCGAATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References