Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1035351..1035938 Replicon chromosome
Accession NZ_CP007035
Organism Niabella soli DSM 19437

Toxin (Protein)


Gene name PumA Uniprot ID W0EV65
Locus tag NIASO_RS04335 Protein ID WP_025298701.1
Coordinates 1035351..1035650 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W0F020
Locus tag NIASO_RS04340 Protein ID WP_008583186.1
Coordinates 1035654..1035938 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIASO_RS04315 1031107..1032156 + 1050 WP_008583195.1 ABC transporter permease -
NIASO_RS04320 1032218..1032499 - 282 WP_008583193.1 DUF721 domain-containing protein -
NIASO_RS04325 1032656..1034011 + 1356 WP_044046275.1 hypothetical protein -
NIASO_RS04330 1034129..1035097 + 969 WP_008583189.1 peptidoglycan DD-metalloendopeptidase family protein -
NIASO_RS04335 1035351..1035650 + 300 WP_025298701.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIASO_RS04340 1035654..1035938 + 285 WP_008583186.1 putative addiction module antidote protein Antitoxin
NIASO_RS04345 1035977..1037104 - 1128 WP_008583184.1 DUF1624 domain-containing protein -
NIASO_RS04350 1037161..1038243 - 1083 WP_052356611.1 DNA replication and repair protein RecF -
NIASO_RS04355 1038721..1039716 + 996 WP_008583181.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
NIASO_RS04360 1039741..1040439 + 699 WP_008583179.1 tetratricopeptide repeat protein -
NIASO_RS04365 1040439..1040915 + 477 WP_008583177.1 6,7-dimethyl-8-ribityllumazine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11811.84 Da        Isoelectric Point: 10.2169

>T45969 WP_025298701.1 NZ_CP007035:1035351-1035650 [Niabella soli DSM 19437]
MYFIEKTIEFDKWLRKLRDLRAKAKILFRIQKLENEEHFGDCKSVGNGINELKINYSKGYRIYFKETNGKIIILLIGGDK
SSQQKDIEKAKEIWEKLKK

Download         Length: 300 bp

>T45969 NZ_CP007035:1035351-1035650 [Niabella soli DSM 19437]
ATGTACTTTATTGAAAAAACCATAGAATTTGACAAATGGCTGAGGAAATTGAGGGACTTACGTGCAAAAGCAAAAATTTT
GTTTAGAATTCAAAAATTGGAAAATGAAGAACATTTTGGCGATTGTAAATCTGTTGGAAATGGAATTAATGAATTGAAAA
TTAACTATTCGAAAGGTTATAGAATCTATTTCAAAGAAACAAATGGGAAAATTATCATTTTGCTCATCGGAGGAGACAAA
TCGAGCCAGCAGAAAGACATTGAAAAAGCAAAAGAAATTTGGGAAAAATTGAAGAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10111.61 Da        Isoelectric Point: 4.5960

>AT45969 WP_008583186.1 NZ_CP007035:1035654-1035938 [Niabella soli DSM 19437]
METSKFDIADYLDSNETIAEYLNVLLEEGNESEIIAGIGHIAKAIGMTKIAEETGLSRPSLYKALSEGARPQFSTIMKIL
KAVGGQIRIAPISA

Download         Length: 285 bp

>AT45969 NZ_CP007035:1035654-1035938 [Niabella soli DSM 19437]
ATGGAAACCTCAAAATTTGATATTGCAGATTATTTAGATAGCAATGAGACGATTGCTGAATATCTTAATGTACTTTTAGA
AGAAGGAAACGAGTCTGAAATAATTGCAGGAATCGGGCATATCGCAAAAGCGATAGGAATGACTAAAATTGCTGAAGAAA
CAGGGCTTAGCCGGCCAAGCTTATACAAAGCCTTATCTGAAGGTGCCAGGCCTCAGTTTTCAACAATAATGAAAATTTTG
AAAGCCGTAGGCGGGCAAATCAGAATAGCTCCCATATCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W0EV65

Antitoxin

Source ID Structure
AlphaFold DB W0F020

References