Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2365506..2366133 Replicon chromosome
Accession NZ_CP007033
Organism Dehalobacter restrictus DSM 9455 strain PER-K23

Toxin (Protein)


Gene name pemK Uniprot ID K4L4V2
Locus tag DEHRE_RS11375 Protein ID WP_015043684.1
Coordinates 2365506..2365856 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1C2Y501
Locus tag DEHRE_RS11380 Protein ID WP_019225279.1
Coordinates 2365846..2366133 (-) Length 96 a.a.

Genomic Context

DEHRE_RS11395DEHRE_RS11355DEHRE_RS11360DEHRE_RS11365DEHRE_RS11370DEHRE_RS11375DEHRE_RS11380DEHRE_RS11385DEHRE_RS11390DEHRE_RS11400DEHRE_RS11405DEHRE_RS11410
Location: 2368762..2369311 (550 bp)
Type: Others
Protein ID: Protein_2263
Location: 2360549..2361259 (711 bp)
Type: Others
Protein ID: WP_019225283.1
Location: 2361332..2361757 (426 bp)
Type: Others
Protein ID: WP_025206046.1
Location: 2361775..2362998 (1224 bp)
Type: Others
Protein ID: WP_025206047.1
Location: 2363196..2365334 (2139 bp)
Type: Others
Protein ID: WP_019225280.1
Location: 2365506..2365856 (351 bp)
Type: Toxin
Protein ID: WP_015043684.1
Location: 2365846..2366133 (288 bp)
Type: Antitoxin
Protein ID: WP_019225279.1
Location: 2366293..2367093 (801 bp)
Type: Others
Protein ID: WP_019225278.1
Location: 2367090..2368517 (1428 bp)
Type: Others
Protein ID: WP_025206048.1
Location: 2369379..2369819 (441 bp)
Type: Others
Protein ID: WP_025206049.1
Location: 2369836..2370333 (498 bp)
Type: Others
Protein ID: WP_025206050.1
Location: 2370376..2370804 (429 bp)
Type: Others
Protein ID: WP_025206051.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DEHRE_RS113552360549..2361259-711WP_019225283.1tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB-
DEHRE_RS113602361332..2361757-426WP_025206046.1tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE-
DEHRE_RS113652361775..2362998-1224WP_025206047.1amidohydrolase family protein-
DEHRE_RS113702363196..2365334-2139WP_019225280.1RNA-binding transcriptional accessory protein-
DEHRE_RS113752365506..2365856-351WP_015043684.1type II toxin-antitoxin system PemK/MazF family toxinToxin
DEHRE_RS113802365846..2366133-288WP_019225279.1hypothetical proteinAntitoxin
DEHRE_RS113852366293..2367093-801WP_019225278.1glutamine amidotransferase-
DEHRE_RS113902367090..2368517-1428WP_025206048.1Mur ligase family protein-
DEHRE_RS113952368762..2369311+550Protein_2263gamma carbonic anhydrase family protein-
DEHRE_RS114002369379..2369819-441WP_025206049.1MOSC domain-containing protein-
DEHRE_RS114052369836..2370333-498WP_025206050.1molybdopterin-guanine dinucleotide biosynthesis protein B-
DEHRE_RS114102370376..2370804-429WP_025206051.1sulfurase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-38)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12801.78 Da        Isoelectric Point: 5.2375

>T45968 WP_015043684.1 NZ_CP007033:c2365856-2365506 [Dehalobacter restrictus DSM 9455]
MSIKRGEIFYAELNPVVGSEQGGTRPVLVIQNDIGNQYSPTTIIAAITSQISKAKLPTHVEVKAKRSGLERDSVILTEQI
RTIDKSRLKEKVAVLDEEVMLRVDEAIEISLGLTEI

Download         Length: 351 bp

>T45968 NZ_CP007033:c2365856-2365506 [Dehalobacter restrictus DSM 9455]
ATGAGTATTAAACGCGGGGAGATTTTTTATGCGGAACTAAACCCCGTTGTAGGTTCTGAACAAGGCGGCACCAGGCCGGT
CTTGGTTATTCAGAATGATATTGGAAACCAGTATAGCCCGACAACAATTATCGCAGCAATTACATCCCAGATTTCAAAAG
CCAAACTGCCGACCCATGTGGAAGTCAAAGCTAAACGAAGCGGTTTGGAAAGAGATTCTGTTATTTTGACTGAACAAATC
AGAACGATCGATAAGAGCCGGTTGAAGGAAAAAGTCGCAGTGCTCGACGAGGAAGTAATGCTCAGGGTTGATGAAGCTAT
TGAAATAAGCCTTGGGCTGACGGAGATCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10996.59 Da        Isoelectric Point: 4.3854

>AT45968 WP_019225279.1 NZ_CP007033:c2366133-2365846 [Dehalobacter restrictus DSM 9455]
MAETRRIVVCLPESIIEEVDEIVSSEKLNRSDFIKEAVYSVLIERRKAGIREQMRQGYVEMAQINLSMAVDLCQAEEEAT
MRYEGKLAWSVGYEY

Download         Length: 288 bp

>AT45968 NZ_CP007033:c2366133-2365846 [Dehalobacter restrictus DSM 9455]
TTGGCAGAGACTAGGCGTATTGTTGTATGTTTGCCGGAAAGCATTATTGAGGAAGTAGACGAAATCGTATCGTCAGAGAA
GTTAAACCGGAGTGATTTTATCAAAGAAGCTGTTTACAGTGTATTGATTGAACGGCGAAAAGCAGGAATACGAGAGCAGA
TGCGGCAGGGATATGTTGAAATGGCTCAAATCAACCTGTCGATGGCAGTAGATTTATGCCAGGCTGAAGAAGAGGCAACC
ATGCGTTATGAAGGGAAACTAGCTTGGAGTGTCGGGTATGAGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBK4L4V2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1C2Y501

References