Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1581107..1582667 Replicon chromosome
Accession NZ_CP007030
Organism Thiomicrospira aerophila AL3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag THIAE_RS07775 Protein ID WP_204205764.1
Coordinates 1581107..1582393 (-) Length 429 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag THIAE_RS07780 Protein ID WP_006460673.1
Coordinates 1582425..1582667 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THIAE_RS07755 1576130..1577050 + 921 WP_006460668.1 MBL fold metallo-hydrolase -
THIAE_RS07760 1577082..1578503 + 1422 WP_006460669.1 two-component sensor histidine kinase -
THIAE_RS07765 1578503..1579870 + 1368 WP_157868732.1 sigma-54 dependent transcriptional regulator -
THIAE_RS07770 1579974..1581044 + 1071 WP_157868733.1 ACR3 family arsenite efflux transporter -
THIAE_RS07775 1581107..1582393 - 1287 WP_204205764.1 HipA domain-containing protein Toxin
THIAE_RS07780 1582425..1582667 - 243 WP_006460673.1 helix-turn-helix domain-containing protein Antitoxin
THIAE_RS07785 1582839..1583639 + 801 WP_006460674.1 TOBE domain-containing protein -
THIAE_RS07790 1583747..1584511 + 765 WP_006460675.1 molybdate ABC transporter substrate-binding protein -
THIAE_RS07795 1584545..1585240 + 696 WP_006460676.1 molybdate ABC transporter permease subunit -
THIAE_RS07800 1585245..1586321 + 1077 WP_006460677.1 molybdenum ABC transporter ATP-binding protein -
THIAE_RS07805 1586326..1586928 + 603 Protein_1527 sulfite exporter TauE/SafE family protein -
THIAE_RS07810 1587137..1587421 - 285 WP_006460679.1 putative addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-55)


Sequences

Toxin        


Download         Length: 429 a.a.        Molecular weight: 47771.24 Da        Isoelectric Point: 8.5510

>T45965 WP_204205764.1 NZ_CP007030:c1582393-1581107 [Thiomicrospira aerophila AL3]
MNGLRVGKLIKHKNGALRFSYAKEWLVSPYSRALSLSLPLSEKPYEGDLIYNFLDNLLPDNDLIRAKMQTRFKTATIQPF
DLLAAVGKDCVGAIQLTSHAPVGDSQYNAGLDATELNESQIADLLKNYAANPLGMQDLEQDFRISLAGAQEKTALLKIDD
KWYLPKGATPTTHILKLPIGVLAHNNLDLSQSCENEWLCMQIAGAFGLPVAHTEVLEFDGQKAIAVERFDRKWLANDRLV
RLPQEDMCQVLGIAPALKYEADGGPSIKQIMDVLRGSQQAQRDREVFFKAQILFWLLAAPDGHGKNFSLFIEANNGYRLT
PLYDILSAYPLMGGQGLQPQKIKMAMALQGKSRHYKWHSLSPRHFVMTAKAVGYSERLALSHLEEMCQKAEQVITQVKSR
LPAHFPENISQPIFDGMLKKAKIGLSLK

Download         Length: 1287 bp

>T45965 NZ_CP007030:c1582393-1581107 [Thiomicrospira aerophila AL3]
ATGAATGGTTTACGGGTCGGTAAGTTGATTAAACACAAGAATGGTGCTTTGCGTTTCAGCTATGCCAAAGAATGGCTGGT
TTCACCTTATTCGCGTGCTTTGTCCTTGTCCCTCCCATTGTCAGAAAAACCGTATGAAGGCGATTTGATTTACAATTTTT
TAGATAACCTACTGCCTGATAATGATTTGATTCGCGCCAAAATGCAGACGAGATTCAAGACAGCAACGATCCAGCCATTT
GATTTGTTGGCAGCGGTGGGCAAAGATTGTGTAGGTGCTATTCAATTGACCAGCCATGCACCTGTTGGGGATTCACAATA
TAACGCAGGGCTTGATGCGACAGAATTGAATGAATCTCAAATTGCCGATTTGTTAAAAAACTATGCCGCCAATCCTTTAG
GTATGCAGGATTTGGAGCAAGATTTTCGTATTTCCCTTGCCGGTGCGCAAGAAAAGACAGCGTTACTCAAGATAGACGAT
AAATGGTATTTGCCTAAAGGCGCAACCCCAACCACGCATATTCTAAAATTGCCGATTGGTGTGTTAGCGCATAATAACCT
TGATTTGTCGCAAAGTTGTGAAAACGAATGGTTGTGTATGCAAATTGCCGGCGCGTTCGGATTGCCGGTCGCGCATACCG
AGGTATTGGAATTTGACGGCCAAAAGGCGATTGCGGTTGAACGCTTTGATCGTAAATGGTTGGCTAATGACCGATTAGTA
CGTTTACCGCAAGAGGATATGTGTCAAGTCTTAGGTATTGCACCGGCACTTAAATATGAGGCGGACGGTGGGCCAAGTAT
CAAACAGATTATGGATGTTCTGCGTGGCTCACAGCAGGCTCAACGGGATCGAGAGGTCTTTTTTAAAGCACAAATTCTGT
TCTGGTTATTAGCGGCACCGGATGGGCATGGTAAAAATTTCAGTCTGTTTATTGAAGCGAATAATGGCTATCGCTTAACG
CCGCTTTATGACATTTTGTCTGCTTATCCTTTGATGGGTGGGCAGGGATTACAGCCTCAAAAAATAAAAATGGCGATGGC
GTTACAGGGTAAATCTCGACATTACAAATGGCACAGCCTTAGCCCAAGACATTTTGTTATGACCGCCAAAGCGGTGGGCT
ACTCAGAACGTCTTGCTTTAAGTCATCTTGAAGAGATGTGCCAGAAAGCAGAACAGGTGATTACACAGGTTAAGTCCCGG
TTGCCGGCACATTTTCCTGAAAATATTTCCCAGCCTATTTTTGACGGCATGTTAAAAAAAGCCAAGATCGGTTTGAGTTT
AAAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8981.30 Da        Isoelectric Point: 5.0180

>AT45965 WP_006460673.1 NZ_CP007030:c1582667-1582425 [Thiomicrospira aerophila AL3]
MRVNSIKELAVVLQNQRLSLDISQSQLAELACTRQATVSNFENNPAQAKIETLFKLLSALELELEVRPKGSLAQDNKLDW

Download         Length: 243 bp

>AT45965 NZ_CP007030:c1582667-1582425 [Thiomicrospira aerophila AL3]
ATGCGGGTAAACAGCATTAAAGAGCTGGCGGTGGTGTTGCAGAATCAACGCTTATCGTTGGATATTTCGCAAAGTCAGTT
GGCGGAGTTAGCGTGTACACGCCAAGCGACGGTGTCAAATTTTGAAAATAATCCTGCGCAAGCAAAGATTGAAACCTTAT
TTAAATTATTGTCCGCGCTAGAACTTGAGCTGGAAGTCCGCCCCAAAGGGTCGTTAGCGCAGGATAACAAGCTTGATTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References