Detailed information of TA system TA045964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1398322..1398982
• Replicon: chromosome
• Accession: NZ_CP007030
• Organism: Thiomicrospira aerophila AL3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THIAE_RS06825
• Protein ID: WP_006461072.1
• Coordinates: 1398322..1398747 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: W0DW74
• Locus tag: THIAE_RS06830
• Protein ID: WP_006461073.1
• Coordinates: 1398740..1398982 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIAE_RS06790	1393600..1394604	-	1005	WP_006461064.1	SEC-C domain-containing protein	-
THIAE_RS06795	1394624..1394914	-	291	WP_006461065.1	helix-turn-helix domain-containing protein	-
THIAE_RS06800	1395333..1395692	-	360	WP_041483057.1	type II toxin-antitoxin system PemK/MazF family toxin	-
THIAE_RS06805	1395695..1395937	-	243	WP_006461068.1	ribbon-helix-helix protein, CopG family	-
THIAE_RS10815	1396089..1396178	-	90	Protein_1329	hypothetical protein	-
THIAE_RS06810	1396280..1396525	+	246	WP_006461069.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
THIAE_RS06815	1396509..1396910	+	402	WP_025299355.1	type II toxin-antitoxin system VapC family toxin	-
THIAE_RS06820	1397092..1398309	+	1218	WP_006461071.1	IS256 family transposase	-
THIAE_RS06825	1398322..1398747	-	426	WP_006461072.1	type II toxin-antitoxin system VapC family toxin	Toxin
THIAE_RS06830	1398740..1398982	-	243	WP_006461073.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
THIAE_RS06835	1399479..1400861	-	1383	WP_041483258.1	deoxyguanosinetriphosphate triphosphohydrolase family protein	-
THIAE_RS06840	1400871..1402283	-	1413	WP_006461075.1	glutamate--tRNA ligase	-
THIAE_RS06845	1402551..1403324	+	774	WP_006461076.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (9-55)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15782.07 Da
• Isoelectric Point: 6.2194

>T45964 WP_006461072.1 NZ_CP007030:c1398747-1398322 [Thiomicrospira aerophila AL3]
MIKYLLDTNICIYVIKRRPIEVLSRFNEAAGHLAISSITLAELLHGVEKSQHTSKNLQAVEDFCSRLDVIEYDPKAAAHY
GEIRAELELTGTTIGVNDLHIAGHARSLGTILVTNNMKEFERVEGLRLQNWISLEPVNNSV

Nucleotide

• Length: 426 bp

>T45964 NZ_CP007030:c1398747-1398322 [Thiomicrospira aerophila AL3]
ATGATTAAATATTTGCTGGATACAAATATCTGCATTTATGTGATTAAACGTCGCCCGATTGAAGTGCTAAGCAGGTTTAA
TGAAGCGGCTGGGCATTTGGCTATTTCATCGATTACACTTGCTGAACTTTTACACGGCGTAGAAAAAAGCCAACATACGA
GCAAAAACCTGCAAGCTGTGGAAGATTTTTGTAGTCGATTAGACGTTATAGAATATGACCCAAAAGCAGCCGCTCATTAC
GGTGAAATTCGTGCCGAACTTGAACTTACCGGAACGACTATTGGAGTGAATGATCTTCACATTGCTGGTCATGCAAGAAG
CCTTGGTACAATTTTAGTCACCAACAACATGAAAGAATTTGAGCGAGTTGAAGGATTGAGATTGCAGAACTGGATAAGTT
TAGAGCCTGTAAATAATTCTGTGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9227.33 Da
• Isoelectric Point: 4.7863

>AT45964 WP_006461073.1 NZ_CP007030:c1398982-1398740 [Thiomicrospira aerophila AL3]
MITATVFENNKTQAVRLPVAVRFESSVKKVFVRKQGKERIITPVENTWDSFFLSPTTSVTDDFLNERAEQTETPRESFDD

Nucleotide

• Length: 243 bp

>AT45964 NZ_CP007030:c1398982-1398740 [Thiomicrospira aerophila AL3]
ATGATTACAGCGACGGTTTTTGAAAACAACAAAACTCAAGCAGTACGCTTACCTGTAGCTGTTCGGTTTGAATCTTCAGT
CAAAAAGGTATTTGTTAGAAAACAGGGTAAAGAGCGCATCATCACGCCGGTTGAAAATACCTGGGATAGTTTTTTCTTAT
CTCCGACAACATCTGTGACTGACGATTTTTTAAACGAACGTGCCGAACAAACTGAAACACCCAGAGAATCTTTCGATGAT
TAA

Structures

Antitoxin

• AlphaFold DB: W0DW74