Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1195131..1195753 Replicon chromosome
Accession NZ_CP007030
Organism Thiomicrospira aerophila AL3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag THIAE_RS05780 Protein ID WP_006460463.1
Coordinates 1195131..1195529 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag THIAE_RS05785 Protein ID WP_204205760.1
Coordinates 1195526..1195753 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THIAE_RS10850 1192164..1192313 - 150 WP_204205734.1 DUF1016 family protein -
THIAE_RS05760 1192417..1193163 - 747 WP_006460459.1 putative DNA binding domain-containing protein -
THIAE_RS05765 1193242..1193685 - 444 WP_006460460.1 hypothetical protein -
THIAE_RS05770 1193703..1194116 - 414 WP_006460461.1 DEAD/DEAH box helicase family protein -
THIAE_RS05775 1194319..1195134 + 816 WP_006460462.1 WYL domain-containing protein -
THIAE_RS05780 1195131..1195529 - 399 WP_006460463.1 tRNA(fMet)-specific endonuclease VapC Toxin
THIAE_RS05785 1195526..1195753 - 228 WP_204205760.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
THIAE_RS10855 1196121..1196318 - 198 WP_204205736.1 hypothetical protein -
THIAE_RS05795 1196681..1197103 - 423 WP_041483054.1 hypothetical protein -
THIAE_RS05800 1197245..1198066 + 822 WP_006460467.1 ion transporter -
THIAE_RS05805 1198129..1199721 - 1593 WP_006460468.1 ABC-F family ATPase -
THIAE_RS05810 1199816..1200244 - 429 WP_006460469.1 CopD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15019.32 Da        Isoelectric Point: 8.4534

>T45962 WP_006460463.1 NZ_CP007030:c1195529-1195131 [Thiomicrospira aerophila AL3]
MIKYLLDTNILIYTLKNRPKQVRDTFNRHVMQMAVSTITVGELVYGAERSAQPERNLADIEGLIARLDVLDFDTQAATHF
GQIRAELYAKGQPIGPYDMMIAGHARSRGLILVSNNLKEFERVSSLRLENWV

Download         Length: 399 bp

>T45962 NZ_CP007030:c1195529-1195131 [Thiomicrospira aerophila AL3]
ATGATTAAGTATCTGCTCGATACCAATATCTTGATTTACACCTTAAAAAATCGACCTAAGCAAGTCCGGGACACATTTAA
TCGCCATGTGATGCAGATGGCTGTGTCGACAATTACAGTAGGGGAACTGGTCTATGGTGCCGAACGTTCCGCTCAGCCTG
AACGTAATCTTGCTGATATAGAAGGCTTAATCGCACGCCTAGACGTATTAGATTTTGATACCCAAGCGGCCACGCATTTT
GGTCAGATCCGTGCTGAGTTGTATGCCAAAGGACAGCCGATTGGTCCTTACGATATGATGATTGCTGGCCATGCGCGAAG
CAGGGGGCTTATTTTGGTGAGCAATAACCTTAAAGAGTTTGAACGTGTGTCAAGTTTAAGGTTGGAGAATTGGGTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8495.48 Da        Isoelectric Point: 4.3867

>AT45962 WP_204205760.1 NZ_CP007030:c1195753-1195526 [Thiomicrospira aerophila AL3]
ITTTVFKNNQSQAVRLPKSVALDEGVKQVVITALGKTRIISPLEQSWDDWFDSKGVSEDFMSEREQEPDQTREAL

Download         Length: 228 bp

>AT45962 NZ_CP007030:c1195753-1195526 [Thiomicrospira aerophila AL3]
ATTACAACGACCGTGTTTAAAAATAATCAATCTCAGGCGGTGCGCTTGCCCAAGTCGGTTGCGCTTGATGAGGGTGTTAA
GCAAGTTGTTATAACAGCGCTGGGTAAAACGCGCATTATTAGCCCGCTAGAGCAAAGCTGGGATGATTGGTTTGACTCTA
AAGGTGTGAGTGAAGATTTTATGAGCGAACGTGAACAAGAGCCGGATCAAACCCGAGAAGCGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References