Detailed information of TA system TA045962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1195131..1195753
• Replicon: chromosome
• Accession: NZ_CP007030
• Organism: Thiomicrospira aerophila AL3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THIAE_RS05780
• Protein ID: WP_006460463.1
• Coordinates: 1195131..1195529 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: THIAE_RS05785
• Protein ID: WP_204205760.1
• Coordinates: 1195526..1195753 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THIAE_RS10850	1192164..1192313	-	150	WP_204205734.1	DUF1016 family protein	-
THIAE_RS05760	1192417..1193163	-	747	WP_006460459.1	putative DNA binding domain-containing protein	-
THIAE_RS05765	1193242..1193685	-	444	WP_006460460.1	hypothetical protein	-
THIAE_RS05770	1193703..1194116	-	414	WP_006460461.1	DEAD/DEAH box helicase family protein	-
THIAE_RS05775	1194319..1195134	+	816	WP_006460462.1	WYL domain-containing protein	-
THIAE_RS05780	1195131..1195529	-	399	WP_006460463.1	tRNA(fMet)-specific endonuclease VapC	Toxin
THIAE_RS05785	1195526..1195753	-	228	WP_204205760.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
THIAE_RS10855	1196121..1196318	-	198	WP_204205736.1	hypothetical protein	-
THIAE_RS05795	1196681..1197103	-	423	WP_041483054.1	hypothetical protein	-
THIAE_RS05800	1197245..1198066	+	822	WP_006460467.1	ion transporter	-
THIAE_RS05805	1198129..1199721	-	1593	WP_006460468.1	ABC-F family ATPase	-
THIAE_RS05810	1199816..1200244	-	429	WP_006460469.1	CopD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15019.32 Da
• Isoelectric Point: 8.4534

>T45962 WP_006460463.1 NZ_CP007030:c1195529-1195131 [Thiomicrospira aerophila AL3]
MIKYLLDTNILIYTLKNRPKQVRDTFNRHVMQMAVSTITVGELVYGAERSAQPERNLADIEGLIARLDVLDFDTQAATHF
GQIRAELYAKGQPIGPYDMMIAGHARSRGLILVSNNLKEFERVSSLRLENWV

Nucleotide

• Length: 399 bp

>T45962 NZ_CP007030:c1195529-1195131 [Thiomicrospira aerophila AL3]
ATGATTAAGTATCTGCTCGATACCAATATCTTGATTTACACCTTAAAAAATCGACCTAAGCAAGTCCGGGACACATTTAA
TCGCCATGTGATGCAGATGGCTGTGTCGACAATTACAGTAGGGGAACTGGTCTATGGTGCCGAACGTTCCGCTCAGCCTG
AACGTAATCTTGCTGATATAGAAGGCTTAATCGCACGCCTAGACGTATTAGATTTTGATACCCAAGCGGCCACGCATTTT
GGTCAGATCCGTGCTGAGTTGTATGCCAAAGGACAGCCGATTGGTCCTTACGATATGATGATTGCTGGCCATGCGCGAAG
CAGGGGGCTTATTTTGGTGAGCAATAACCTTAAAGAGTTTGAACGTGTGTCAAGTTTAAGGTTGGAGAATTGGGTTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8495.48 Da
• Isoelectric Point: 4.3867

>AT45962 WP_204205760.1 NZ_CP007030:c1195753-1195526 [Thiomicrospira aerophila AL3]
ITTTVFKNNQSQAVRLPKSVALDEGVKQVVITALGKTRIISPLEQSWDDWFDSKGVSEDFMSEREQEPDQTREAL

Nucleotide

• Length: 228 bp

>AT45962 NZ_CP007030:c1195753-1195526 [Thiomicrospira aerophila AL3]
ATTACAACGACCGTGTTTAAAAATAATCAATCTCAGGCGGTGCGCTTGCCCAAGTCGGTTGCGCTTGATGAGGGTGTTAA
GCAAGTTGTTATAACAGCGCTGGGTAAAACGCGCATTATTAGCCCGCTAGAGCAAAGCTGGGATGATTGGTTTGACTCTA
AAGGTGTGAGTGAAGATTTTATGAGCGAACGTGAACAAGAGCCGGATCAAACCCGAGAAGCGCTATGA