Detailed information of TA system TA045959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3597557..3598236
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: W0DR28
• Locus tag: THITH_RS16290
• Protein ID: WP_006746735.1
• Coordinates: 3597817..3598236 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: W0DMM0
• Locus tag: THITH_RS16285
• Protein ID: WP_006746736.1
• Coordinates: 3597557..3597820 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS16260	3593281..3593763	+	483	WP_006746741.1	CBS domain-containing protein	-
THITH_RS16265	3593776..3595065	+	1290	WP_198019518.1	arsenic transporter	-
THITH_RS16270	3595285..3596247	+	963	WP_006746739.1	bile acid:sodium symporter	-
THITH_RS16275	3596431..3596703	-	273	WP_006746738.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
THITH_RS16280	3596703..3596960	-	258	WP_006746737.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
THITH_RS16285	3597557..3597820	+	264	WP_006746736.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
THITH_RS16290	3597817..3598236	+	420	WP_006746735.1	type II toxin-antitoxin system VapC family toxin	Toxin
THITH_RS18610	3598451..3598591	-	141	WP_156925543.1	hypothetical protein	-
THITH_RS16295	3599059..3599643	+	585	WP_156925544.1	hypothetical protein	-
THITH_RS16300	3600329..3603211	+	2883	WP_041483923.1	VWA domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-126)

Antitoxin

• SpoVT-AbrB domain (11-42)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15427.59 Da
• Isoelectric Point: 6.2310

>T45959 WP_006746735.1 NZ_CP007029:3597817-3598236 [Thioalkalivibrio paradoxus ARh 1]
VTYLLDTNILIYLIKNRPPGIGQRIDDLPDADELCMSFVTWAELLKGAERSTRKAEVVRRLEALARQVPVRYPAGPGICR
HYAEQATRLKDSGTPIGANDLWIACHALAEDATLVTHNTREFGRIGGLRIEDWAASAET

Nucleotide

• Length: 420 bp

>T45959 NZ_CP007029:3597817-3598236 [Thioalkalivibrio paradoxus ARh 1]
GTGACCTACCTGCTTGACACCAACATCCTGATCTACTTGATCAAGAATCGGCCGCCGGGCATTGGACAGCGTATCGATGA
TTTACCCGACGCCGATGAACTGTGCATGTCCTTTGTCACATGGGCCGAATTGCTCAAAGGGGCCGAGCGAAGCACGCGCA
AAGCCGAGGTCGTTCGCCGGCTTGAAGCCCTCGCGCGGCAGGTGCCGGTGCGTTACCCGGCCGGACCAGGCATCTGCCGT
CACTATGCAGAGCAGGCCACGCGTCTCAAAGACAGCGGTACCCCCATCGGCGCCAACGATCTATGGATCGCGTGCCACGC
GCTGGCGGAAGACGCCACTCTCGTAACCCACAATACCCGCGAGTTTGGCCGCATCGGCGGCCTGAGAATCGAGGACTGGG
CGGCATCCGCCGAGACTTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9577.73 Da
• Isoelectric Point: 4.3855

>AT45959 WP_006746736.1 NZ_CP007029:3597557-3597820 [Thioalkalivibrio paradoxus ARh 1]
MGTLTTRVFNNGNSQAVRIPAEFRLDTDRVSISRNEDGDLVIHPLPAQRGTALMQTLQALSEVDDAFVAALEAEQRSSLP
VQEREVL

Nucleotide

• Length: 264 bp

>AT45959 NZ_CP007029:3597557-3597820 [Thioalkalivibrio paradoxus ARh 1]
ATGGGGACACTGACCACTCGCGTCTTCAACAACGGCAACAGTCAGGCGGTTCGCATTCCCGCCGAGTTCCGGCTGGACAC
CGATCGTGTGAGCATCTCCCGCAACGAGGACGGCGATCTCGTGATTCATCCGCTACCCGCGCAGCGCGGCACGGCACTGA
TGCAGACGCTACAGGCACTGAGCGAGGTCGATGACGCCTTCGTTGCCGCGCTGGAGGCCGAACAGCGTTCGTCCCTGCCG
GTGCAGGAGCGTGAGGTTCTGTGA

Structures

Toxin

• AlphaFold DB: W0DR28

Antitoxin

• AlphaFold DB: W0DMM0