Detailed information of TA system TA045958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafQ-relB/YafQ-RelB
• Location: 3596431..3596960
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: W0DM88
• Locus tag: THITH_RS16275
• Protein ID: WP_006746738.1
• Coordinates: 3596431..3596703 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W0DS65
• Locus tag: THITH_RS16280
• Protein ID: WP_006746737.1
• Coordinates: 3596703..3596960 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS16250	3591685..3592020	+	336	WP_025367658.1	metalloregulator ArsR/SmtB family transcription factor	-
THITH_RS16255	3592155..3593174	+	1020	WP_006746742.1	ArsJ-associated glyceraldehyde-3-phosphate dehydrogenase	-
THITH_RS16260	3593281..3593763	+	483	WP_006746741.1	CBS domain-containing protein	-
THITH_RS16265	3593776..3595065	+	1290	WP_198019518.1	arsenic transporter	-
THITH_RS16270	3595285..3596247	+	963	WP_006746739.1	bile acid:sodium symporter	-
THITH_RS16275	3596431..3596703	-	273	WP_006746738.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
THITH_RS16280	3596703..3596960	-	258	WP_006746737.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
THITH_RS16285	3597557..3597820	+	264	WP_006746736.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
THITH_RS16290	3597817..3598236	+	420	WP_006746735.1	type II toxin-antitoxin system VapC family toxin	-
THITH_RS18610	3598451..3598591	-	141	WP_156925543.1	hypothetical protein	-
THITH_RS16295	3599059..3599643	+	585	WP_156925544.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10509.16 Da
• Isoelectric Point: 10.4452

>T45958 WP_006746738.1 NZ_CP007029:c3596703-3596431 [Thioalkalivibrio paradoxus ARh 1]
MLTAVRSSQFKRDVKRLQKRGKDMGKLRILLGLLIEKAPLPEGYQDHSLRGNWRGYRDAHIEPDWLLLYRVVGDELHLAR
TGSHADLFRE

Nucleotide

• Length: 273 bp

>T45958 NZ_CP007029:c3596703-3596431 [Thioalkalivibrio paradoxus ARh 1]
ATGCTGACTGCGGTCCGTTCCAGCCAGTTCAAACGCGATGTGAAACGGCTTCAGAAACGTGGCAAGGATATGGGCAAGTT
GCGGATTCTGTTGGGCCTGCTGATTGAGAAGGCCCCATTGCCGGAGGGGTACCAGGATCACTCCTTGCGAGGAAACTGGC
GTGGCTACCGAGACGCACATATCGAGCCGGATTGGTTGCTGCTGTACCGCGTTGTCGGCGACGAGTTGCACTTGGCCCGG
ACCGGTAGCCATGCGGATCTGTTCCGCGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9291.71 Da
• Isoelectric Point: 5.1351

>AT45958 WP_006746737.1 NZ_CP007029:c3596960-3596703 [Thioalkalivibrio paradoxus ARh 1]
MSADTVVRARIDSETKKRATAALEAMGLSVSDAIRLLMLRIADEQRLPFTVQVPNALTAKALEDLESGKGKRFDSAEELF
KDLGI

Nucleotide

• Length: 258 bp

>AT45958 NZ_CP007029:c3596960-3596703 [Thioalkalivibrio paradoxus ARh 1]
ATGAGTGCGGATACTGTGGTTCGAGCTCGTATCGACAGCGAAACCAAAAAGCGTGCCACCGCGGCCTTGGAGGCCATGGG
GTTGTCGGTGTCCGACGCGATCCGCTTGCTGATGCTGCGCATTGCCGATGAACAGCGACTTCCCTTCACGGTTCAGGTGC
CCAACGCGCTTACTGCCAAGGCGCTGGAAGACCTGGAATCTGGTAAAGGAAAGCGGTTCGATAGTGCTGAGGAGCTCTTC
AAGGACTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: W0DM88

Antitoxin

• AlphaFold DB: W0DS65