Detailed information of TA system TA045957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3557732..3558463
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THITH_RS16100
• Protein ID: WP_006746776.1
• Coordinates: 3557732..3558208 (-)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: W0DM32
• Locus tag: THITH_RS16105
• Protein ID: WP_006746775.1
• Coordinates: 3558209..3558463 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS16075	3553532..3553807	+	276	WP_006746780.1	accessory factor UbiK family protein	-
THITH_RS16080	3554163..3555671	+	1509	WP_006746779.1	YifB family Mg chelatase-like AAA ATPase	-
THITH_RS18315	3555690..3556085	-	396	WP_084222721.1	c-type cytochrome	-
THITH_RS16090	3556335..3557138	-	804	Protein_3217	c-type cytochrome	-
THITH_RS16100	3557732..3558208	-	477	WP_006746776.1	type II toxin-antitoxin system VapC family toxin	Toxin
THITH_RS16105	3558209..3558463	-	255	WP_006746775.1	hypothetical protein	Antitoxin
THITH_RS16110	3558852..3559823	-	972	WP_006746774.1	VTT domain-containing protein	-
THITH_RS16115	3559820..3560716	-	897	WP_025367654.1	sterol desaturase family protein	-
THITH_RS16120	3561176..3561853	-	678	WP_025367655.1	metalloregulator ArsR/SmtB family transcription factor	-
THITH_RS18605	3562033..3562176	+	144	WP_156925541.1	hypothetical protein	-
THITH_RS16125	3562391..3562669	+	279	WP_006746770.1	type II toxin-antitoxin system RelE/ParE family toxin	-
THITH_RS16130	3562681..3562953	+	273	WP_006746769.1	HigA family addiction module antidote protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 17233.76 Da
• Isoelectric Point: 7.1652

>T45957 WP_006746776.1 NZ_CP007029:c3558208-3557732 [Thioalkalivibrio paradoxus ARh 1]
MIVLDTNVVFEAMRPEPDATVRAWLNDQAAGTLYLSSVPLAELLFGIRALPAGKRKNLLDRALTELLELFKNRVLPFDTD
AARHYADLTVTARNGGRGFPTPDGYIAAIAASKGFIVASRDTSPYEASGVTVINPWGAMTERYANCHGQRPPPMMKEA

Nucleotide

• Length: 477 bp

>T45957 NZ_CP007029:c3558208-3557732 [Thioalkalivibrio paradoxus ARh 1]
ATGATTGTCCTGGATACCAACGTCGTTTTCGAGGCGATGAGGCCGGAGCCGGACGCGACCGTGAGGGCTTGGCTGAACGA
CCAGGCGGCCGGGACCTTGTACCTGTCCAGCGTCCCCCTGGCCGAGTTGCTGTTCGGCATCCGGGCGTTGCCAGCGGGAA
AGCGCAAGAACCTGCTCGATCGCGCCCTGACCGAGCTGCTGGAGCTGTTCAAGAATCGGGTCTTGCCGTTCGACACCGAT
GCAGCGCGCCACTATGCCGACCTGACCGTGACAGCCAGAAACGGCGGGCGCGGCTTTCCGACGCCGGACGGCTACATCGC
GGCCATTGCCGCATCGAAAGGATTCATTGTGGCATCACGAGACACCTCGCCCTATGAAGCGTCTGGCGTGACCGTCATCA
ACCCTTGGGGGGCGATGACCGAACGCTACGCTAACTGTCATGGCCAGCGGCCACCCCCGATGATGAAAGAGGCGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9265.57 Da
• Isoelectric Point: 8.8736

>AT45957 WP_006746775.1 NZ_CP007029:c3558463-3558209 [Thioalkalivibrio paradoxus ARh 1]
MAILTVRNVPDDVHRALRVRAAQHGRSTEAEVREILATAVNPEKRVRVSEALAAIGRKIGLTDDDFAVFESVRDKTPAKP
LSFD

Nucleotide

• Length: 255 bp

>AT45957 NZ_CP007029:c3558463-3558209 [Thioalkalivibrio paradoxus ARh 1]
ATGGCGATCCTGACTGTAAGGAACGTGCCTGATGACGTGCACCGCGCTTTGCGCGTGCGGGCGGCTCAACACGGCCGCAG
CACGGAAGCCGAGGTGCGCGAGATTCTGGCAACCGCGGTCAATCCGGAGAAGCGCGTGCGCGTGAGCGAGGCCCTGGCCG
CCATCGGCCGCAAGATCGGTCTGACCGACGATGATTTCGCCGTCTTCGAGAGTGTGCGCGACAAGACGCCGGCCAAACCG
TTGAGCTTCGACTGA

Structures

Antitoxin

• AlphaFold DB: W0DM32