Detailed information of TA system TA045956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 3246504..3247131
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: W0DQW5
• Locus tag: THITH_RS14610
• Protein ID: WP_006747071.1
• Coordinates: 3246504..3246800 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W0DLB2
• Locus tag: THITH_RS14615
• Protein ID: WP_006747070.1
• Coordinates: 3246805..3247131 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS14570	3241603..3241791	-	189	WP_006747081.1	hypothetical protein	-
THITH_RS14575	3241808..3242077	-	270	WP_006747080.1	hypothetical protein	-
THITH_RS18240	3242802..3243446	+	645	WP_156925533.1	DUF1566 domain-containing protein	-
THITH_RS14580	3243930..3244136	+	207	WP_006747077.1	hypothetical protein	-
THITH_RS14585	3244133..3244360	+	228	WP_198019451.1	superinfection immunity protein	-
THITH_RS14590	3244381..3244581	+	201	WP_025367600.1	hypothetical protein	-
THITH_RS14595	3244588..3245166	-	579	WP_006747074.1	hypothetical protein	-
THITH_RS14600	3245440..3245643	-	204	WP_006747073.1	hypothetical protein	-
THITH_RS14605	3245643..3246389	-	747	WP_006747072.1	hypothetical protein	-
THITH_RS14610	3246504..3246800	+	297	WP_006747071.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
THITH_RS14615	3246805..3247131	+	327	WP_006747070.1	putative addiction module antidote protein	Antitoxin
THITH_RS14625	3247429..3249915	-	2487	WP_006747069.1	lytic transglycosylase domain-containing protein	-
THITH_RS14630	3250254..3250475	-	222	WP_006747068.1	hypothetical protein	-
THITH_RS14635	3250475..3250837	-	363	WP_006747067.1	hypothetical protein	-
THITH_RS14640	3250901..3251269	-	369	WP_006747066.1	hypothetical protein	-
THITH_RS14645	3251290..3251472	-	183	WP_006747065.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3237093..3265361	28268

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (3-102)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11026.65 Da
• Isoelectric Point: 10.2138

>T45956 WP_006747071.1 NZ_CP007029:3246504-3246800 [Thioalkalivibrio paradoxus ARh 1]
MVTIQTTSSFDAWFESLRDRQGKARIAARLRRVEMGHMGDVKAIGKGVQEMRIDCGPGYRIYFTQRGIEIVILLAGGDKD
SQRRDIRAATELARQIGD

Nucleotide

• Length: 297 bp

>T45956 NZ_CP007029:3246504-3246800 [Thioalkalivibrio paradoxus ARh 1]
ATGGTCACGATCCAGACAACCAGTTCGTTCGATGCGTGGTTCGAGTCCCTGCGGGACCGGCAGGGCAAGGCGCGGATCGC
AGCCCGGCTGCGGCGCGTAGAGATGGGGCACATGGGCGACGTGAAGGCGATCGGCAAGGGCGTGCAGGAGATGCGGATCG
ACTGCGGACCCGGATACCGGATCTACTTCACCCAGCGGGGCATCGAGATCGTGATCTTATTGGCTGGTGGCGACAAGGAC
TCCCAGCGACGGGACATCCGCGCGGCCACCGAACTGGCCCGGCAGATTGGAGACTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11918.60 Da
• Isoelectric Point: 6.0765

>AT45956 WP_006747070.1 NZ_CP007029:3246805-3247131 [Thioalkalivibrio paradoxus ARh 1]
MTTVTLKRWDVVDHLRTDEDMALYLDACFAEDPGDGSLIRVALGDIARAHGMTQLARDTGMAREGLYKALSAEGNPEFAT
IMKVVRALRLRLHAHSANENREPGILAQ

Nucleotide

• Length: 327 bp

>AT45956 NZ_CP007029:3246805-3247131 [Thioalkalivibrio paradoxus ARh 1]
ATGACCACCGTGACGCTGAAGCGCTGGGACGTGGTGGACCACCTCCGCACTGACGAGGACATGGCCCTCTATCTCGACGC
CTGCTTCGCTGAGGATCCAGGGGACGGGAGCCTGATCCGGGTCGCTCTCGGAGACATTGCCCGAGCACACGGCATGACCC
AACTGGCCCGGGATACCGGCATGGCTCGCGAGGGTCTGTACAAGGCGCTGTCCGCTGAAGGGAATCCGGAGTTCGCGACG
ATCATGAAGGTCGTGCGAGCCCTCCGGCTTCGGCTGCATGCCCACAGCGCGAACGAGAACCGCGAGCCGGGCATCCTGGC
GCAGTAG

Structures

Toxin

• AlphaFold DB: W0DQW5

Antitoxin

• AlphaFold DB: W0DLB2