Detailed information of TA system TA045955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2388655..2389762
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: -
• Uniprot ID: W0DNA0
• Locus tag: THITH_RS10770
• Protein ID: WP_006748085.1
• Coordinates: 2389016..2389762 (+)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: L0DUX6
• Locus tag: THITH_RS10765
• Protein ID: WP_006748086.1
• Coordinates: 2388655..2389014 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS10730	2383743..2384006	-	264	WP_006748093.1	Txe/YoeB family addiction module toxin	-
THITH_RS10735	2384003..2384245	-	243	WP_006748092.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
THITH_RS10740	2384450..2384983	-	534	WP_156925584.1	Uma2 family endonuclease	-
THITH_RS18550	2385222..2385470	-	249	WP_156925519.1	type II toxin-antitoxin system VapC family toxin	-
THITH_RS18800	2385373..2385600	-	228	WP_084222657.1	DUF86 domain-containing protein	-
THITH_RS10750	2385773..2386042	+	270	WP_006748089.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
THITH_RS10755	2386039..2386455	+	417	WP_006748088.1	type II toxin-antitoxin system VapC family toxin	-
THITH_RS10760	2386498..2388336	-	1839	WP_198019510.1	NERD domain-containing protein	-
THITH_RS10765	2388655..2389014	+	360	WP_006748086.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
THITH_RS10770	2389016..2389762	+	747	WP_006748085.1	RES family NAD+ phosphorylase	Toxin
THITH_RS10775	2389983..2390159	-	177	Protein_2160	type II toxin-antitoxin system VapC family toxin	-
THITH_RS10780	2390192..2390467	-	276	WP_006748083.1	helix-turn-helix domain-containing protein	-
THITH_RS10785	2390761..2393751	-	2991	WP_041483432.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2350521..2402746	52225

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (62-208)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-117)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 28366.24 Da
• Isoelectric Point: 9.1832

>T45955 WP_006748085.1 NZ_CP007029:2389016-2389762 [Thioalkalivibrio paradoxus ARh 1]
MPDWAAWVDTAPRVVLKGEVLRLVESQEQVATNQLVSSLERQAVLEEMLESTKPPLRPGTERLHYLLATPFRYPPLRHGS
RFGRRHEPSLFYGALGERTVLAEAAYYRFVFWYGMATPPPRKLDTQHTLFAARYQGRDGIQLHQPPFEDSTPLLRHPADY
SATQALGTAMREAGIDLFEYRSARDTEAGLNLALYHPRPFTRKTPTRQDAWLCQLTAEHARFRKTGDGTLQDFALEQFLH
RGRLPLPA

Nucleotide

• Length: 747 bp

>T45955 NZ_CP007029:2389016-2389762 [Thioalkalivibrio paradoxus ARh 1]
ATGCCCGATTGGGCGGCATGGGTCGACACCGCGCCCCGCGTGGTCCTGAAAGGAGAAGTCCTGCGCCTGGTCGAGAGTCA
GGAGCAGGTGGCCACCAACCAACTGGTGTCGTCGCTGGAACGCCAGGCGGTGTTGGAAGAGATGCTGGAATCGACCAAAC
CGCCGCTGCGTCCGGGCACCGAGCGGCTGCATTACCTGCTGGCGACGCCGTTTCGCTACCCCCCGCTACGCCATGGCTCG
CGCTTCGGTCGGCGCCATGAACCGAGCCTGTTCTACGGGGCGCTGGGCGAACGCACGGTACTCGCGGAAGCGGCCTACTA
CCGCTTCGTCTTCTGGTACGGAATGGCCACCCCGCCGCCGCGCAAGCTCGATACCCAGCACACGCTGTTTGCCGCCCGGT
ACCAGGGGCGTGACGGTATCCAGCTCCATCAGCCTCCGTTCGAGGACAGCACCCCCCTGCTCCGCCATCCCGCCGACTAC
AGCGCCACCCAGGCATTGGGCACCGCGATGCGCGAGGCCGGCATCGACCTGTTCGAGTACCGCTCGGCGCGGGATACGGA
GGCGGGCCTCAACCTTGCGCTCTACCATCCGCGCCCGTTCACTCGAAAGACACCCACCCGGCAGGATGCCTGGCTCTGCC
AGTTGACCGCCGAGCACGCGCGCTTCCGGAAAACCGGCGACGGTACGCTGCAGGATTTCGCGCTCGAGCAGTTCCTGCAC
CGCGGCCGCCTGCCGCTGCCGGCATGA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 12578.53 Da
• Isoelectric Point: 8.9978

>AT45955 WP_006748086.1 NZ_CP007029:2388655-2389014 [Thioalkalivibrio paradoxus ARh 1]
MGSVTALAPQRAEVLREALVNAGKALGLTQAELGAVIGRGRTDISRGNVDPDSKPGELALLLIRCYRALYVLTGGDAGAM
KHWMHTPNHHTGGVPAEQIRSVQGLVGVLEYLDAIRGKI

Nucleotide

• Length: 360 bp

>AT45955 NZ_CP007029:2388655-2389014 [Thioalkalivibrio paradoxus ARh 1]
ATGGGTAGTGTTACGGCTCTGGCTCCTCAGCGCGCGGAGGTCCTGCGCGAGGCGCTGGTCAATGCCGGCAAGGCATTGGG
CCTGACCCAGGCGGAACTGGGCGCGGTGATCGGGCGCGGGCGCACGGACATCAGCAGGGGCAACGTCGATCCGGACAGCA
AGCCGGGGGAACTGGCGTTGCTGCTGATCCGCTGCTATCGCGCCCTGTACGTGCTCACCGGAGGGGACGCCGGCGCGATG
AAGCACTGGATGCACACGCCCAACCACCACACCGGGGGCGTGCCGGCCGAGCAGATCCGCTCGGTGCAGGGCCTGGTGGG
CGTGCTCGAATACCTCGACGCCATCCGCGGCAAGATCTGA

Structures

Toxin

• AlphaFold DB: W0DNA0

Antitoxin

• AlphaFold DB: L0DUX6