Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2385773..2386455 Replicon chromosome
Accession NZ_CP007029
Organism Thioalkalivibrio paradoxus ARh

Toxin (Protein)


Gene name vapC Uniprot ID W0DJE5
Locus tag THITH_RS10755 Protein ID WP_006748088.1
Coordinates 2386039..2386455 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID W0DNZ8
Locus tag THITH_RS10750 Protein ID WP_006748089.1
Coordinates 2385773..2386042 (+) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
THITH_RS18795 2381326..2381481 - 156 WP_198019442.1 type II toxin-antitoxin system RelE/ParE family toxin -
THITH_RS17985 2381633..2381821 - 189 WP_006748097.1 hypothetical protein -
THITH_RS18540 2381950..2382303 - 354 WP_156925517.1 hypothetical protein -
THITH_RS18545 2382419..2383081 - 663 WP_006748096.1 hypothetical protein -
THITH_RS10725 2383192..2383686 + 495 WP_156925518.1 hypothetical protein -
THITH_RS10730 2383743..2384006 - 264 WP_006748093.1 Txe/YoeB family addiction module toxin -
THITH_RS10735 2384003..2384245 - 243 WP_006748092.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
THITH_RS10740 2384450..2384983 - 534 WP_156925584.1 Uma2 family endonuclease -
THITH_RS18550 2385222..2385470 - 249 WP_156925519.1 type II toxin-antitoxin system VapC family toxin -
THITH_RS18800 2385373..2385600 - 228 WP_084222657.1 DUF86 domain-containing protein -
THITH_RS10750 2385773..2386042 + 270 WP_006748089.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
THITH_RS10755 2386039..2386455 + 417 WP_006748088.1 type II toxin-antitoxin system VapC family toxin Toxin
THITH_RS10760 2386498..2388336 - 1839 WP_198019510.1 NERD domain-containing protein -
THITH_RS10765 2388655..2389014 + 360 WP_006748086.1 MbcA/ParS/Xre antitoxin family protein -
THITH_RS10770 2389016..2389762 + 747 WP_006748085.1 RES family NAD+ phosphorylase -
THITH_RS10775 2389983..2390159 - 177 Protein_2160 type II toxin-antitoxin system VapC family toxin -
THITH_RS10780 2390192..2390467 - 276 WP_006748083.1 helix-turn-helix domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2350521..2402746 52225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-127)

Antitoxin

(10-58)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 15187.64 Da        Isoelectric Point: 7.5167

>T45954 WP_006748088.1 NZ_CP007029:2386039-2386455 [Thioalkalivibrio paradoxus ARh 1]
MTSVLHMLDTDTTSYIIKGHSPVLESRLAEIPPDRLCISAVTRAELMYGLKRLAPAHRLHLAVGQFLKIVRVPAWGADAA
DYYADIRYRLTRSGQPIGEMDMMIAAHALAVGAVLVSNNTGHFERIDAPLALTNWLHG

Download         Length: 417 bp

>T45954 NZ_CP007029:2386039-2386455 [Thioalkalivibrio paradoxus ARh 1]
ATGACCAGCGTTTTGCACATGCTCGATACGGATACGACGAGCTACATCATCAAGGGGCATTCGCCGGTCCTCGAGTCGAG
ACTCGCCGAAATACCGCCCGATCGGCTATGCATATCCGCCGTCACACGCGCTGAGCTGATGTACGGCCTCAAGCGATTGG
CACCCGCTCATCGGCTGCATCTGGCGGTGGGCCAGTTTCTCAAGATCGTGCGCGTACCTGCCTGGGGCGCTGACGCGGCG
GACTACTACGCAGATATCCGATACCGGTTGACCCGATCGGGCCAGCCGATTGGTGAAATGGACATGATGATCGCCGCCCA
CGCGCTCGCTGTCGGCGCTGTATTGGTGAGCAACAACACCGGGCATTTCGAGCGCATCGACGCACCATTGGCGTTAACCA
ACTGGTTGCACGGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10246.54 Da        Isoelectric Point: 4.5370

>AT45954 WP_006748089.1 NZ_CP007029:2385773-2386042 [Thioalkalivibrio paradoxus ARh 1]
MTETRRVKLFKNGASQAVRLPAEFRFENEEIYATRDDASGDVVLSTRPGAKIWAEFFALIRTVDVPDDFMAERPMNIVPH
ERDLFQDEA

Download         Length: 270 bp

>AT45954 NZ_CP007029:2385773-2386042 [Thioalkalivibrio paradoxus ARh 1]
ATGACTGAAACCCGACGTGTCAAGCTGTTCAAGAATGGTGCGAGTCAGGCTGTCCGCTTGCCGGCTGAGTTTCGTTTCGA
GAACGAGGAGATTTACGCCACCAGGGACGATGCGTCTGGCGACGTCGTGCTGTCCACCCGGCCAGGGGCCAAGATCTGGG
CTGAGTTTTTTGCACTGATACGGACCGTTGATGTCCCGGACGACTTCATGGCAGAGCGTCCAATGAACATCGTTCCCCAT
GAACGCGACCTCTTTCAGGACGAAGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB W0DJE5


Antitoxin

Source ID Structure
AlphaFold DB W0DNZ8

References