Detailed information of TA system TA045953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 2374702..2375237
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: W0DPC5
• Locus tag: THITH_RS10695
• Protein ID: WP_006748103.1
• Coordinates: 2374950..2375237 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W0DJD7
• Locus tag: THITH_RS10690
• Protein ID: WP_006748104.1
• Coordinates: 2374702..2374953 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS10675	2370330..2370575	+	246	WP_006748107.1	DUF1049 domain-containing protein	-
THITH_RS10680	2370608..2374012	-	3405	WP_006748106.1	DEAD/DEAH box helicase family protein	-
THITH_RS10685	2374009..2374404	-	396	WP_006748105.1	hypothetical protein	-
THITH_RS10690	2374702..2374953	+	252	WP_006748104.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
THITH_RS10695	2374950..2375237	+	288	WP_006748103.1	Txe/YoeB family addiction module toxin	Toxin
THITH_RS17965	2375257..2375535	-	279	WP_006748102.1	YgiT-type zinc finger protein	-
THITH_RS17970	2375532..2375963	-	432	WP_198019441.1	DUF4258 domain-containing protein	-
THITH_RS10705	2376526..2377785	-	1260	WP_006748101.1	ATP-binding protein	-
THITH_RS10710	2378055..2379236	-	1182	WP_006748100.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2350521..2402746	52225

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11488.06 Da
• Isoelectric Point: 9.8037

>T45953 WP_006748103.1 NZ_CP007029:2374950-2375237 [Thioalkalivibrio paradoxus ARh 1]
VKLIFADEAWEDYLYWQKQDKKMVERINKLIRETQREPFSGIGKPERLKHALSGFWSRRITDEHRLVYRVEDDALQIAQL
RFHYSEAQRRPSPAT

Nucleotide

• Length: 288 bp

>T45953 NZ_CP007029:2374950-2375237 [Thioalkalivibrio paradoxus ARh 1]
GTGAAGCTGATCTTCGCTGACGAGGCATGGGAAGACTACCTATATTGGCAGAAGCAGGACAAGAAGATGGTCGAGCGGAT
CAACAAGCTGATTCGCGAGACCCAGCGCGAACCCTTTTCCGGCATTGGCAAGCCGGAGCGGCTAAAGCATGCTCTCTCCG
GTTTCTGGTCACGCCGCATCACGGATGAACACCGCCTGGTGTACCGAGTTGAAGACGATGCCCTCCAGATAGCTCAACTG
CGCTTCCACTATTCAGAGGCCCAACGTCGGCCATCACCCGCCACTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9120.52 Da
• Isoelectric Point: 9.5990

>AT45953 WP_006748104.1 NZ_CP007029:2374702-2374953 [Thioalkalivibrio paradoxus ARh 1]
VDAITYTTVRANLSKTMDRVCSDHEALIITRNGQQSVVMLSLEDYKALEETAYLLRTPANAKRLLTAAAQLNAGKGVERK
LAK

Nucleotide

• Length: 252 bp

>AT45953 NZ_CP007029:2374702-2374953 [Thioalkalivibrio paradoxus ARh 1]
GTGGATGCTATTACCTACACAACCGTTCGGGCCAACCTCTCCAAGACTATGGATCGGGTTTGCAGTGACCACGAAGCCTT
GATTATTACGCGCAACGGACAGCAGTCCGTCGTGATGCTCTCGCTTGAGGATTACAAAGCGTTGGAGGAAACCGCCTATC
TTCTGCGCACGCCTGCAAACGCGAAGCGCCTTCTCACCGCGGCGGCACAACTGAACGCTGGGAAAGGCGTTGAGCGCAAG
CTGGCCAAGTGA

Structures

Toxin

• AlphaFold DB: W0DPC5

Antitoxin

• AlphaFold DB: W0DJD7