Detailed information of TA system TA045952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1866557..1867188
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: THITH_RS08540
• Protein ID: WP_006747488.1
• Coordinates: 1866787..1867188 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: W0DM64
• Locus tag: THITH_RS08535
• Protein ID: WP_006747489.1
• Coordinates: 1866557..1866787 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS08520	1862288..1863667	-	1380	WP_006747492.1	class II fumarate hydratase	-
THITH_RS08525	1863855..1865231	+	1377	WP_006747491.1	adenylosuccinate lyase	-
THITH_RS08530	1865245..1866423	+	1179	WP_006747490.1	cupin domain-containing protein	-
THITH_RS08535	1866557..1866787	+	231	WP_006747489.1	antitoxin	Antitoxin
THITH_RS08540	1866787..1867188	+	402	WP_006747488.1	tRNA(fMet)-specific endonuclease VapC	Toxin
THITH_RS08545	1867268..1867930	-	663	WP_041483701.1	VTT domain-containing protein	-
THITH_RS08550	1868765..1869208	+	444	WP_051418647.1	FixH family protein	-
THITH_RS08555	1869378..1869881	+	504	WP_006747485.1	hypothetical protein	-
THITH_RS08560	1870055..1870576	+	522	WP_006747484.1	zeta toxin family protein	-
THITH_RS08565	1870573..1870800	+	228	WP_006747483.1	hypothetical protein	-
THITH_RS08570	1870969..1871199	-	231	WP_006747482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-52)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14939.18 Da
• Isoelectric Point: 7.8842

>T45952 WP_006747488.1 NZ_CP007029:1866787-1867188 [Thioalkalivibrio paradoxus ARh 1]
MLKYMLDTNFCIFTIKNKPPTVRQRFEQHTGQMCISTVTLMELVYGSEKSVAPARNLEVIEGFVARLEVLDYDRSAAEHS
GQLRAELARLGTPIGPFDQMIAGHARSRGLIVITSNRGEFGRVPGLRVEDWNT

Nucleotide

• Length: 402 bp

>T45952 NZ_CP007029:1866787-1867188 [Thioalkalivibrio paradoxus ARh 1]
ATGCTGAAGTACATGTTGGACACCAACTTCTGCATCTTCACCATCAAGAACAAACCCCCGACCGTTCGCCAGCGCTTTGA
GCAACATACCGGCCAGATGTGCATCAGCACGGTGACGCTGATGGAGCTGGTCTACGGGTCCGAGAAATCCGTGGCACCGG
CCAGGAATCTCGAGGTCATCGAAGGCTTCGTGGCCAGACTGGAAGTGCTCGACTACGACCGCAGTGCGGCGGAGCATTCC
GGACAACTCAGGGCCGAACTGGCTCGACTGGGCACGCCGATCGGCCCGTTTGACCAGATGATCGCGGGTCATGCGCGCAG
TCGCGGATTGATCGTGATCACCAGCAACCGGGGGGAGTTCGGTCGGGTGCCGGGTCTTCGCGTAGAGGACTGGAATACCT
GA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8581.68 Da
• Isoelectric Point: 5.0152

>AT45952 WP_006747489.1 NZ_CP007029:1866557-1866787 [Thioalkalivibrio paradoxus ARh 1]
MDQAAVFKSNRSQAIRLPKSVALPEDVKRVNVIAIGRVRILTPVGESWDGWFDGPGVTDDFLVDRDQPQDQRREAF

Nucleotide

• Length: 231 bp

>AT45952 NZ_CP007029:1866557-1866787 [Thioalkalivibrio paradoxus ARh 1]
ATGGACCAGGCCGCAGTCTTCAAGAGTAATCGCAGCCAAGCCATCCGGCTGCCCAAGTCGGTCGCGCTGCCCGAGGATGT
GAAACGAGTGAATGTCATCGCGATCGGCCGGGTGCGCATCCTTACTCCGGTGGGTGAGTCCTGGGATGGCTGGTTCGATG
GTCCAGGCGTGACCGACGATTTCCTGGTCGACAGGGATCAACCGCAAGACCAGCGGCGTGAGGCATTTTGA

Structures

Antitoxin

• AlphaFold DB: W0DM64