Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pasABC/RelE-HTH |
| Location | 1183546..1184086 | Replicon | chromosome |
| Accession | NZ_CP007029 | ||
| Organism | Thioalkalivibrio paradoxus ARh | ||
Toxin (Protein)
| Gene name | pasB | Uniprot ID | - |
| Locus tag | THITH_RS17675 | Protein ID | WP_006748722.1 |
| Coordinates | 1183754..1184086 (+) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | pasA | Uniprot ID | L0DTP4 |
| Locus tag | THITH_RS05390 | Protein ID | WP_006748723.1 |
| Coordinates | 1183546..1183770 (+) | Length | 75 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| THITH_RS05365 | 1179283..1180044 | - | 762 | WP_006748727.1 | hypothetical protein | - |
| THITH_RS05370 | 1180295..1181146 | - | 852 | WP_006748726.1 | hypothetical protein | - |
| THITH_RS05375 | 1181151..1182164 | - | 1014 | WP_156925567.1 | undecaprenyl/decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase | - |
| THITH_RS05380 | 1182835..1183086 | + | 252 | Protein_1089 | nucleotidyltransferase domain-containing protein | - |
| THITH_RS05385 | 1183096..1183374 | + | 279 | WP_025367681.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| THITH_RS05390 | 1183546..1183770 | + | 225 | WP_006748723.1 | TraY domain-containing protein | Antitoxin |
| THITH_RS17675 | 1183754..1184086 | + | 333 | WP_006748722.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| THITH_RS05400 | 1184083..1184310 | + | 228 | WP_006748721.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| THITH_RS05405 | 1184300..1184740 | + | 441 | WP_006748720.1 | type II toxin-antitoxin system VapC family toxin | - |
| THITH_RS05410 | 1184966..1185220 | + | 255 | WP_006748719.1 | hypothetical protein | - |
| THITH_RS05415 | 1185210..1185545 | + | 336 | WP_006748718.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| THITH_RS05420 | 1185635..1185874 | + | 240 | Protein_1097 | MarR family EPS-associated transcriptional regulator | - |
| THITH_RS05425 | 1186247..1186495 | + | 249 | WP_006748716.1 | hypothetical protein | - |
| THITH_RS05430 | 1186492..1186911 | + | 420 | WP_006748715.1 | type II toxin-antitoxin system VapC family toxin | - |
| THITH_RS05435 | 1187983..1188507 | + | 525 | WP_006749129.1 | hypothetical protein | - |
| THITH_RS17695 | 1188651..1188971 | + | 321 | WP_084222623.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | bplA / bplB | 1182814..1255455 | 72641 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 13153.25 Da Isoelectric Point: 11.0257
>T45951 WP_006748722.1 NZ_CP007029:1183754-1184086 [Thioalkalivibrio paradoxus ARh 1]
MSWTIEFDRRVEKDLRALDKPSARRILKYLNERIAPLDDPRRLGMSLTGELGEYWRYRVGQYRIIASIEDERLRVLVVRV
AHRNEVYRQGLGARHVLRSEIMQHIPRGIR
MSWTIEFDRRVEKDLRALDKPSARRILKYLNERIAPLDDPRRLGMSLTGELGEYWRYRVGQYRIIASIEDERLRVLVVRV
AHRNEVYRQGLGARHVLRSEIMQHIPRGIR
Download Length: 333 bp
>T45951 NZ_CP007029:1183754-1184086 [Thioalkalivibrio paradoxus ARh 1]
TTGAGTTGGACGATTGAATTTGATCGCCGCGTCGAGAAAGACCTGCGTGCATTGGACAAGCCATCAGCACGCCGGATTCT
GAAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCGCGGCGTCTGGGCATGTCGCTGACCGGGGAATTGGGCGAAT
ACTGGCGCTACCGCGTGGGTCAGTACCGAATCATTGCATCGATAGAAGATGAACGGCTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGAGGTCTATCGCCAGGGCCTCGGGGCTCGCCATGTGCTACGATCCGAAATAATGCAGCACATACCAAG
AGGTATCCGATGA
TTGAGTTGGACGATTGAATTTGATCGCCGCGTCGAGAAAGACCTGCGTGCATTGGACAAGCCATCAGCACGCCGGATTCT
GAAATACCTGAACGAGCGTATCGCGCCATTGGACGACCCGCGGCGTCTGGGCATGTCGCTGACCGGGGAATTGGGCGAAT
ACTGGCGCTACCGCGTGGGTCAGTACCGAATCATTGCATCGATAGAAGATGAACGGCTTCGGGTGCTGGTGGTGCGTGTG
GCTCACCGCAATGAGGTCTATCGCCAGGGCCTCGGGGCTCGCCATGTGCTACGATCCGAAATAATGCAGCACATACCAAG
AGGTATCCGATGA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8587.70 Da Isoelectric Point: 4.6899
>AT45951 WP_006748723.1 NZ_CP007029:1183546-1183770 [Thioalkalivibrio paradoxus ARh 1]
MLALRLPEDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSGETVSMDEMRRRLELDD
MLALRLPEDVEERLAALAKATGRSKSYYAREAILQHLDDLEDIYLAEQRLIDHRKGSGETVSMDEMRRRLELDD
Download Length: 225 bp
>AT45951 NZ_CP007029:1183546-1183770 [Thioalkalivibrio paradoxus ARh 1]
ATGCTCGCGTTACGGCTTCCTGAGGATGTGGAAGAACGCCTGGCTGCCCTCGCCAAGGCCACCGGTAGAAGCAAAAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATCTACCTGGCTGAACAGCGCCTGATCGATCACC
GCAAAGGAAGCGGCGAGACAGTGTCCATGGATGAAATGAGGCGCCGGCTTGAGTTGGACGATTGA
ATGCTCGCGTTACGGCTTCCTGAGGATGTGGAAGAACGCCTGGCTGCCCTCGCCAAGGCCACCGGTAGAAGCAAAAGCTA
CTACGCCCGCGAGGCGATCCTGCAGCATCTGGACGATCTGGAAGACATCTACCTGGCTGAACAGCGCCTGATCGATCACC
GCAAAGGAAGCGGCGAGACAGTGTCCATGGATGAAATGAGGCGCCGGCTTGAGTTGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|