Detailed information of TA system TA045942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 237833..238491
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: W0DEN8
• Locus tag: THITH_RS01115
• Protein ID: WP_006746361.1
• Coordinates: 238087..238491 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: W0DJC7
• Locus tag: THITH_RS01110
• Protein ID: WP_006746362.1
• Coordinates: 237833..238087 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS01085	233225..234118	+	894	WP_006746368.1	hypothetical protein	-
THITH_RS01090	234304..235440	+	1137	WP_006746367.1	hypothetical protein	-
THITH_RS01095	235654..235878	+	225	WP_006746366.1	addiction module protein	-
THITH_RS17315	236270..236473	+	204	WP_006746365.1	type II toxin-antitoxin system HicB family antitoxin	-
THITH_RS17320	236470..236676	+	207	WP_084222591.1	type II toxin-antitoxin system HicA family toxin	-
THITH_RS01100	236901..237284	-	384	WP_006746364.1	type II toxin-antitoxin system death-on-curing family toxin	-
THITH_RS01105	237288..237518	-	231	WP_006746363.1	hypothetical protein	-
THITH_RS01110	237833..238087	+	255	WP_006746362.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
THITH_RS01115	238087..238491	+	405	WP_006746361.1	type II toxin-antitoxin system VapC family toxin	Toxin
THITH_RS01120	238724..239896	+	1173	WP_006746360.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-83)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14724.64 Da
• Isoelectric Point: 5.6643

>T45942 WP_006746361.1 NZ_CP007029:238087-238491 [Thioalkalivibrio paradoxus ARh 1]
MVIDTSALVAILQDEPERHAFNEAIEAAESRLLSVANWVETSIVIEVRYGTAGLHLFDRFLDRAAIECVPVDLRQAKEAR
RAFSQYGKGRHPAGLNYGDCFAYALARTNGQPLLFKGDDFARTDIAPSIGSAAR

Nucleotide

• Length: 405 bp

>T45942 NZ_CP007029:238087-238491 [Thioalkalivibrio paradoxus ARh 1]
ATGGTCATCGATACCTCGGCGCTGGTTGCCATTCTCCAGGACGAGCCGGAACGGCACGCTTTCAACGAAGCCATCGAGGC
TGCGGAGTCGCGCTTGCTTTCGGTGGCCAACTGGGTCGAGACGTCCATCGTGATCGAGGTGCGCTACGGCACGGCGGGGC
TGCATCTGTTCGACCGATTCCTGGATCGCGCAGCGATCGAGTGCGTGCCCGTGGATCTTCGGCAGGCCAAGGAGGCGCGT
CGTGCCTTCAGCCAGTACGGCAAGGGGCGACACCCCGCCGGCCTGAATTACGGTGACTGTTTCGCCTATGCGCTGGCGCG
CACGAATGGCCAGCCGCTGCTGTTCAAGGGTGACGATTTCGCCCGCACGGACATCGCCCCAAGCATTGGCTCAGCCGCCC
GGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9410.60 Da
• Isoelectric Point: 5.8920

>AT45942 WP_006746362.1 NZ_CP007029:237833-238087 [Thioalkalivibrio paradoxus ARh 1]
MALNIRNPEADRLAAELAQATGETKTEAVIQAMRDRLNRVRRERGGTRLADELDEIARACAALPVRDRRSAEEILGYDEH
GLPR

Nucleotide

• Length: 255 bp

>AT45942 NZ_CP007029:237833-238087 [Thioalkalivibrio paradoxus ARh 1]
ATGGCGCTGAATATCCGAAATCCAGAAGCGGATCGGCTGGCAGCAGAGCTGGCCCAGGCCACGGGTGAAACCAAGACCGA
GGCGGTGATTCAAGCGATGCGGGATCGCCTGAACCGTGTGCGCCGTGAGCGCGGGGGAACGCGGCTCGCGGATGAGCTGG
ACGAGATCGCGCGTGCCTGCGCGGCATTGCCGGTTCGCGATCGCCGCAGTGCGGAGGAGATCCTCGGTTACGACGAGCAC
GGTCTCCCGCGCTGA

Structures

Toxin

• AlphaFold DB: W0DEN8

Antitoxin

• AlphaFold DB: W0DJC7