Detailed information of TA system TA045941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafQ-relB/YafQ-RelB
• Location: 216086..216615
• Replicon: chromosome
• Accession: NZ_CP007029
• Organism: Thioalkalivibrio paradoxus ARh

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: W0DFF5
• Locus tag: THITH_RS01025
• Protein ID: WP_006746381.1
• Coordinates: 216343..216615 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W0DJM8
• Locus tag: THITH_RS01020
• Protein ID: WP_006746382.1
• Coordinates: 216086..216343 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
THITH_RS00995	211421..211609	+	189	WP_006746387.1	hypothetical protein	-
THITH_RS01000	211934..212395	+	462	WP_006746386.1	hypothetical protein	-
THITH_RS01005	212558..212857	+	300	WP_006746385.1	hypothetical protein	-
THITH_RS01010	213167..215005	+	1839	WP_006746384.1	5'-nucleotidase C-terminal domain-containing protein	-
THITH_RS17295	215015..215245	-	231	WP_198019485.1	hypothetical protein	-
THITH_RS01020	216086..216343	+	258	WP_006746382.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
THITH_RS01025	216343..216615	+	273	WP_006746381.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
THITH_RS01030	217094..217390	+	297	Protein_207	type II toxin-antitoxin system RelE/ParE family toxin	-
THITH_RS01035	217395..217721	+	327	WP_006746378.1	putative addiction module antidote protein	-
THITH_RS01040	218402..218635	+	234	WP_006746377.1	DUF433 domain-containing protein	-
THITH_RS01045	218635..218901	+	267	WP_006746376.1	DUF5615 family PIN-like protein	-
THITH_RS01055	219310..219735	+	426	WP_025367164.1	hypothetical protein	-
THITH_RS01060	219914..221077	+	1164	WP_156925551.1	Fic family protein	-
THITH_RS01065	221289..221471	-	183	WP_006746374.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-82)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10539.22 Da
• Isoelectric Point: 10.4452

>T45941 WP_006746381.1 NZ_CP007029:216343-216615 [Thioalkalivibrio paradoxus ARh 1]
MLTAVRSSQFKRDVKRLQKRGKDMGKLRILLGLLIEKAPLPEAYQDHSLRGNWRGYRDAHIELDWLLLYRVVGDELHLAR
TGSHADLFRE

Nucleotide

• Length: 273 bp

>T45941 NZ_CP007029:216343-216615 [Thioalkalivibrio paradoxus ARh 1]
ATGCTGACTGCGGTCCGTTCCAGCCAGTTCAAACGCGATGTGAAACGGCTTCAGAAACGTGGCAAGGATATGGGCAAGTT
GCGGATTCTGTTGGGCCTGCTGATTGAGAAGGCCCCATTGCCGGAGGCGTACCAGGATCACTCCTTGCGAGGAAACTGGC
GTGGCTACCGAGATGCACATATCGAGCTGGATTGGTTGCTGCTGTACCGCGTTGTCGGCGACGAGTTGCACTTGGCCCGG
ACCGGTAGCCATGCGGATCTGTTCCGCGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9263.66 Da
• Isoelectric Point: 5.1070

>AT45941 WP_006746382.1 NZ_CP007029:216086-216343 [Thioalkalivibrio paradoxus ARh 1]
MSADTVVRARIDSETKKRATAALEAMGLSVSDAIRLLMLRIADEQRLPFTVQVPNALTAKALEDLDSGKGKRFDSADELF
KDLGI

Nucleotide

• Length: 258 bp

>AT45941 NZ_CP007029:216086-216343 [Thioalkalivibrio paradoxus ARh 1]
ATGAGTGCGGATACTGTGGTTCGAGCTCGTATCGACAGCGAAACCAAAAAGCGTGCCACTGCGGCCTTGGAGGCCATGGG
GTTGTCGGTGTCCGACGCGATCCGCTTGCTGATGCTGCGCATTGCTGATGAACAGCGACTTCCCTTCACGGTTCAGGTGC
CCAACGCGCTTACTGCCAAGGCGCTGGAAGACCTGGATTCTGGTAAAGGAAAGCGGTTCGATAGTGCTGATGAGCTCTTC
AAGGACTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: W0DFF5

Antitoxin

• AlphaFold DB: W0DJM8