Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707024..3707698 Replicon chromosome
Accession NZ_CP007027
Organism Mycobacterium tuberculosis H37RvSiena

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag Y980_RS17565 Protein ID WP_003417282.1
Coordinates 3707024..3707452 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag Y980_RS17570 Protein ID WP_003417286.1
Coordinates 3707456..3707698 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y980_RS17540 3702846..3703247 - 402 WP_003417264.1 cytidine deaminase -
Y980_RS17545 3703388..3703822 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
Y980_RS17550 3703819..3704253 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
Y980_RS17555 3704382..3706154 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
Y980_RS17560 3706154..3706945 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
Y980_RS17565 3707024..3707452 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
Y980_RS17570 3707456..3707698 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
Y980_RS17575 3707820..3708434 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
Y980_RS17580 3708431..3709096 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
Y980_RS17585 3709097..3709630 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
Y980_RS22820 3709627..3709779 - 153 WP_003916129.1 hypothetical protein -
Y980_RS17600 3709815..3711076 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T45935 WP_003417282.1 NZ_CP007027:c3707452-3707024 [Mycobacterium tuberculosis H37RvSiena]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T45935 NZ_CP007027:c3707452-3707024 [Mycobacterium tuberculosis H37RvSiena]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT45935 WP_003417286.1 NZ_CP007027:c3707698-3707456 [Mycobacterium tuberculosis H37RvSiena]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT45935 NZ_CP007027:c3707698-3707456 [Mycobacterium tuberculosis H37RvSiena]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References