Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3136008..3136612 Replicon chromosome
Accession NZ_CP007027
Organism Mycobacterium tuberculosis H37RvSiena

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag Y980_RS14950 Protein ID WP_003414492.1
Coordinates 3136008..3136400 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P71622
Locus tag Y980_RS14955 Protein ID WP_003912003.1
Coordinates 3136397..3136612 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y980_RS14920 3131158..3131946 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
Y980_RS14925 3132280..3132825 - 546 WP_003913758.1 DUF1802 family protein -
Y980_RS14930 3133097..3133981 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
Y980_RS14935 3133984..3134871 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin -
Y980_RS14940 3135176..3135721 - 546 WP_003899500.1 DUF1802 family protein -
Y980_RS14945 3135718..3135987 - 270 WP_003414489.1 DUF2277 family protein -
Y980_RS14950 3136008..3136400 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
Y980_RS14955 3136397..3136612 - 216 WP_003912003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
Y980_RS14960 3136659..3137408 + 750 WP_003414497.1 enoyl-CoA hydratase -
Y980_RS14965 3137487..3138569 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
Y980_RS14970 3138562..3139872 - 1311 WP_003414501.1 ABC transporter substrate-binding protein -
Y980_RS14975 3139875..3140702 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
Y980_RS14980 3140699..3141610 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T45931 WP_003414492.1 NZ_CP007027:c3136400-3136008 [Mycobacterium tuberculosis H37RvSiena]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T45931 NZ_CP007027:c3136400-3136008 [Mycobacterium tuberculosis H37RvSiena]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7483.50 Da        Isoelectric Point: 4.9732

>AT45931 WP_003912003.1 NZ_CP007027:c3136612-3136397 [Mycobacterium tuberculosis H37RvSiena]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAADDDELFTTGVSWNVS

Download         Length: 216 bp

>AT45931 NZ_CP007027:c3136612-3136397 [Mycobacterium tuberculosis H37RvSiena]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGCGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB P71622

References