Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2929458..2930172 Replicon chromosome
Accession NZ_CP007027
Organism Mycobacterium tuberculosis H37RvSiena

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag Y980_RS13780 Protein ID WP_003413460.1
Coordinates 2929732..2930172 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag Y980_RS13775 Protein ID WP_003413456.1
Coordinates 2929458..2929745 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y980_RS13740 2924880..2925125 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
Y980_RS13745 2925122..2925526 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
Y980_RS13750 2925743..2926363 + 621 WP_003413441.1 DUF4178 domain-containing protein -
Y980_RS13755 2926374..2926868 + 495 WP_003413444.1 DUF2617 family protein -
Y980_RS13760 2926865..2927296 + 432 WP_003899390.1 DUF4247 domain-containing protein -
Y980_RS13765 2927351..2927779 + 429 WP_178121172.1 DUF350 domain-containing protein -
Y980_RS13770 2927776..2929347 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
Y980_RS13775 2929458..2929745 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
Y980_RS13780 2929732..2930172 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
Y980_RS13785 2930193..2930948 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
Y980_RS13790 2931081..2931677 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
Y980_RS13795 2931685..2932530 - 846 WP_003413466.1 acyl-CoA thioesterase II -
Y980_RS13800 2932559..2933458 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
Y980_RS13805 2933586..2934260 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T45925 WP_003413460.1 NZ_CP007027:2929732-2930172 [Mycobacterium tuberculosis H37RvSiena]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T45925 NZ_CP007027:2929732-2930172 [Mycobacterium tuberculosis H37RvSiena]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT45925 WP_003413456.1 NZ_CP007027:2929458-2929745 [Mycobacterium tuberculosis H37RvSiena]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT45925 NZ_CP007027:2929458-2929745 [Mycobacterium tuberculosis H37RvSiena]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References