Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2224802..2225490 Replicon chromosome
Accession NZ_CP007027
Organism Mycobacterium tuberculosis H37RvSiena

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag Y980_RS10410 Protein ID WP_003409958.1
Coordinates 2224802..2225221 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag Y980_RS10415 Protein ID WP_003409968.1
Coordinates 2225230..2225490 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y980_RS10390 2220297..2221145 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
Y980_RS10395 2221108..2222553 - 1446 WP_003899115.1 APC family permease -
Y980_RS10400 2222732..2223418 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
Y980_RS10405 2223609..2224577 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
Y980_RS10410 2224802..2225221 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
Y980_RS10415 2225230..2225490 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
Y980_RS10420 2225633..2227309 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
Y980_RS10425 2227297..2227950 - 654 WP_003409976.1 cutinase Cfp21 -
Y980_RS10430 2228065..2228295 + 231 WP_003409980.1 DUF167 domain-containing protein -
Y980_RS10435 2228380..2229291 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
Y980_RS10440 2229400..2229999 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T45912 WP_003409958.1 NZ_CP007027:c2225221-2224802 [Mycobacterium tuberculosis H37RvSiena]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T45912 NZ_CP007027:c2225221-2224802 [Mycobacterium tuberculosis H37RvSiena]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT45912 WP_003409968.1 NZ_CP007027:c2225490-2225230 [Mycobacterium tuberculosis H37RvSiena]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT45912 NZ_CP007027:c2225490-2225230 [Mycobacterium tuberculosis H37RvSiena]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References