Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3253299..3253950 Replicon chromosome
Accession NZ_CP007025
Organism Escherichia albertii KF1

Toxin (Protein)


Gene name cptA Uniprot ID B1EG01
Locus tag EAKF1_RS16195 Protein ID WP_000244763.1
Coordinates 3253546..3253950 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag EAKF1_RS16190 Protein ID WP_000354046.1
Coordinates 3253299..3253565 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAKF1_RS16165 3249011..3250444 - 1434 WP_025238420.1 6-phospho-beta-glucosidase BglA -
EAKF1_RS16170 3250489..3250800 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
EAKF1_RS16175 3250968..3251627 + 660 WP_000250281.1 hemolysin III family protein -
EAKF1_RS16180 3252067..3253047 - 981 WP_025238421.1 tRNA-modifying protein YgfZ -
EAKF1_RS16185 3253079..3253309 + 231 WP_000181267.1 hypothetical protein -
EAKF1_RS16190 3253299..3253565 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
EAKF1_RS16195 3253546..3253950 + 405 WP_000244763.1 protein YgfX Toxin
EAKF1_RS16200 3253989..3254510 - 522 WP_025238422.1 flavodoxin FldB -
EAKF1_RS16205 3254622..3255518 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
EAKF1_RS16210 3255543..3256253 + 711 WP_000748106.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EAKF1_RS16215 3256259..3257992 + 1734 WP_025238423.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15888.81 Da        Isoelectric Point: 11.1732

>T45866 WP_000244763.1 NZ_CP007025:3253546-3253950 [Escherichia albertii KF1]
VVLWQSDLRVSWRAQWLSLLIHGLVAAAILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVRAPWMIKTGMMLRLLSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIQ

Download         Length: 405 bp

>T45866 NZ_CP007025:3253546-3253950 [Escherichia albertii KF1]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT45866 WP_000354046.1 NZ_CP007025:3253299-3253565 [Escherichia albertii KF1]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT45866 NZ_CP007025:3253299-3253565 [Escherichia albertii KF1]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6P9B3

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References