Detailed information of TA system TA045864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2512024..2512636
• Replicon: chromosome
• Accession: NZ_CP007025
• Organism: Escherichia albertii KF1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9YXE2
• Locus tag: EAKF1_RS12445
• Protein ID: WP_000833473.1
• Coordinates: 2512024..2512209 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: L4IWR9
• Locus tag: EAKF1_RS12450
• Protein ID: WP_000499744.1
• Coordinates: 2512226..2512636 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EAKF1_RS12425	2507488..2508783	+	1296	WP_025238096.1	Fic family protein	-
EAKF1_RS12430	2508891..2510429	+	1539	WP_010327692.1	aldehyde dehydrogenase AldB	-
EAKF1_RS12435	2510470..2511549	-	1080	WP_025238097.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
EAKF1_RS12445	2512024..2512209	+	186	WP_000833473.1	type II toxin-antitoxin system HicA family toxin	Toxin
EAKF1_RS12450	2512226..2512636	+	411	WP_000499744.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EAKF1_RS12455	2512708..2514672	-	1965	WP_025238098.1	glycoside hydrolase family 127 protein	-
EAKF1_RS12460	2514683..2516083	-	1401	WP_025238099.1	MFS transporter	-
EAKF1_RS12465	2516309..2517124	+	816	WP_025238100.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6800.89 Da
• Isoelectric Point: 11.7053

>T45864 WP_000833473.1 NZ_CP007025:2512024-2512209 [Escherichia albertii KF1]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T45864 NZ_CP007025:2512024-2512209 [Escherichia albertii KF1]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15241.15 Da
• Isoelectric Point: 4.5486

>AT45864 WP_000499744.1 NZ_CP007025:2512226-2512636 [Escherichia albertii KF1]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT45864 NZ_CP007025:2512226-2512636 [Escherichia albertii KF1]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Structures

Toxin

• AlphaFold DB: U9YXE2

Antitoxin

• AlphaFold DB: L4IWR9