Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1027482..1028100 Replicon chromosome
Accession NZ_CP007025
Organism Escherichia albertii KF1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag EAKF1_RS05185 Protein ID WP_001280991.1
Coordinates 1027882..1028100 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag EAKF1_RS05180 Protein ID WP_000344798.1
Coordinates 1027482..1027856 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAKF1_RS05170 1022562..1023755 + 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EAKF1_RS05175 1023778..1026927 + 3150 WP_001132500.1 multidrug efflux RND transporter permease subunit -
EAKF1_RS05180 1027482..1027856 + 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
EAKF1_RS05185 1027882..1028100 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
EAKF1_RS05190 1028277..1028834 + 558 WP_025237467.1 maltose O-acetyltransferase -
EAKF1_RS05195 1028941..1029411 + 471 WP_000136188.1 YlaC family protein -
EAKF1_RS05200 1029575..1031125 + 1551 WP_001260378.1 EAL domain-containing protein -
EAKF1_RS05205 1031163..1031522 - 360 WP_038430020.1 DUF1428 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T45856 WP_001280991.1 NZ_CP007025:1027882-1028100 [Escherichia albertii KF1]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T45856 NZ_CP007025:1027882-1028100 [Escherichia albertii KF1]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.32 Da        Isoelectric Point: 4.8989

>AT45856 WP_000344798.1 NZ_CP007025:1027482-1027856 [Escherichia albertii KF1]
IDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp

>AT45856 NZ_CP007025:1027482-1027856 [Escherichia albertii KF1]
ATAGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References