Detailed information of TA system TA045853

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1328289..1328875
• Replicon: chromosome
• Accession: NZ_CP007016
• Organism: Streptococcus mutans UA159-FR

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SMUFR_RS06430
• Protein ID: WP_002263545.1
• Coordinates: 1328684..1328875 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q8DTE7
• Locus tag: SMUFR_RS06425
• Protein ID: WP_002263544.1
• Coordinates: 1328289..1328666 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMUFR_RS06410	1324213..1325964	-	1752	WP_002262719.1	glucan-binding protein	-
SMUFR_RS06415	1326127..1326412	-	286	Protein_1228	helix-turn-helix transcriptional regulator	-
SMUFR_RS06420	1326727..1327620	+	894	WP_002262721.1	LexA family transcriptional regulator IrvR	-
SMUFR_RS06425	1328289..1328666	-	378	WP_002263544.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SMUFR_RS06430	1328684..1328875	-	192	WP_002263545.1	type II toxin-antitoxin system HicA family toxin	Toxin
SMUFR_RS06435	1328972..1329634	-	663	WP_002263546.1	type II-A CRISPR-associated protein Csn2	-
SMUFR_RS06440	1329624..1329968	-	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
SMUFR_RS06445	1329965..1330831	-	867	WP_002352326.1	type II CRISPR-associated endonuclease Cas1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-106)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7139.47 Da
• Isoelectric Point: 10.6223

>T45853 WP_002263545.1 NZ_CP007016:c1328875-1328684 [Streptococcus mutans UA159-FR]
MPLTGKELAKLAINNGWEEVRVRGSHHHFKKDGVSYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T45853 NZ_CP007016:c1328875-1328684 [Streptococcus mutans UA159-FR]
TTGCCATTAACAGGGAAAGAATTAGCTAAATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTATCTTATATTGTGACGATTCCTATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14264.31 Da
• Isoelectric Point: 4.5540

>AT45853 WP_002263544.1 NZ_CP007016:c1328666-1328289 [Streptococcus mutans UA159-FR]
MLKSYPVIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGLVLPISSDIQKISVEDGFATMIQADP
SPYLKNNKAIRKNVTVPEWLIRLADRDRVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT45853 NZ_CP007016:c1328666-1328289 [Streptococcus mutans UA159-FR]
ATGTTAAAATCATATCCTGTAATTTTTCATAAGGAAGAGGAAGGGTATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTGTTGGCATCTTATCTTGATGAAG
GGTTGGTTCTACCCATTTCAAGCGATATTCAGAAAATATCTGTTGAAGATGGTTTTGCGACCATGATTCAAGCTGATCCT
AGTCCTTATCTCAAAAATAACAAAGCTATTCGGAAAAATGTTACCGTGCCTGAGTGGTTGATACGATTAGCAGACCGTGA
CCGAGTAAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA

Structures

Antitoxin

• AlphaFold DB: Q8DTE7