Detailed information of TA system TA045852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 849837..850374
• Replicon: chromosome
• Accession: NZ_CP007016
• Organism: Streptococcus mutans UA159-FR

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q8DUM3
• Locus tag: SMUFR_RS04165
• Protein ID: WP_002262889.1
• Coordinates: 850096..850374 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q8DUM4
• Locus tag: SMUFR_RS04160
• Protein ID: WP_002262888.1
• Coordinates: 849837..850109 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMUFR_RS04145	845179..846783	+	1605	WP_002262884.1	type I restriction-modification system subunit M	-
SMUFR_RS04150	846776..848587	+	1812	WP_002352261.1	restriction endonuclease subunit S	-
SMUFR_RS04155	848618..849763	+	1146	WP_002262887.1	AAA family ATPase	-
SMUFR_RS04160	849837..850109	+	273	WP_002262888.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SMUFR_RS04165	850096..850374	+	279	WP_002262889.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SMUFR_RS04170	850377..853424	+	3048	WP_002262890.1	type I restriction endonuclease subunit R	-
SMUFR_RS04175	853638..854012	+	375	WP_002262891.1	DUF1149 family protein	-
SMUFR_RS04180	854018..854863	+	846	WP_002262892.1	DegV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-76)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10722.79 Da
• Isoelectric Point: 10.2475

>T45852 WP_002262889.1 NZ_CP007016:850096-850374 [Streptococcus mutans UA159-FR]
MLKIKQTRQFKKSLKKVVKQGKDINKLFAIVELLCQKSELPLALRNHELKGRWRGIRELHIESDWLLAYQVLDDELVLLL
IDTGSHAQMLGM

Nucleotide

• Length: 279 bp

>T45852 NZ_CP007016:850096-850374 [Streptococcus mutans UA159-FR]
ATGCTAAAGATTAAGCAAACCAGACAATTTAAGAAATCCTTAAAAAAGGTAGTAAAACAAGGAAAAGATATTAACAAGCT
TTTTGCTATCGTAGAATTATTATGCCAAAAATCAGAACTTCCCTTAGCATTGAGAAATCATGAGTTGAAGGGAAGGTGGA
GAGGCATTAGAGAACTTCATATTGAATCAGACTGGCTGTTAGCCTATCAAGTTTTGGATGACGAACTTGTCTTACTCTTG
ATTGATACAGGTAGTCACGCACAGATGTTAGGAATGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10051.41 Da
• Isoelectric Point: 4.4482

>AT45852 WP_002262888.1 NZ_CP007016:849837-850109 [Streptococcus mutans UA159-FR]
MVVKNKANINIKIDLEDKAAADAIFAHMGLTTSAAVNMFIKRVIDDQALPFTPRVKNTLDIALEQAKNDDVETFDSFDDW
KSEMSAYAKD

Nucleotide

• Length: 273 bp

>AT45852 NZ_CP007016:849837-850109 [Streptococcus mutans UA159-FR]
ATGGTTGTAAAAAATAAAGCAAATATCAATATCAAAATTGATTTGGAAGATAAAGCAGCAGCGGATGCTATTTTTGCTCA
CATGGGTCTAACAACAAGTGCTGCTGTTAATATGTTTATTAAACGTGTCATTGATGATCAAGCTCTGCCATTTACTCCAA
GAGTAAAAAATACTTTGGACATTGCTTTAGAGCAGGCTAAAAATGATGATGTTGAAACTTTTGATAGTTTTGATGATTGG
AAATCAGAGATGAGTGCCTATGCTAAAGATTAA

Structures

Toxin

• AlphaFold DB: Q8DUM3

Antitoxin

• AlphaFold DB: Q8DUM4