45847

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4641198..4641826 Replicon chromosome
Accession NZ_CP007012
Organism Pseudomonas sp. FGI182

Toxin (Protein)


Gene name hicA Uniprot ID V9X276
Locus tag C163_RS20395 Protein ID WP_025340378.1
Coordinates 4641644..4641826 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1L5PZ99
Locus tag C163_RS20390 Protein ID WP_038408384.1
Coordinates 4641198..4641623 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C163_RS20380 4636994..4638334 + 1341 WP_025340375.1 PLP-dependent aminotransferase family protein -
C163_RS20385 4638713..4641154 + 2442 WP_025340376.1 penicillin acylase family protein -
C163_RS20390 4641198..4641623 - 426 WP_038408384.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C163_RS20395 4641644..4641826 - 183 WP_025340378.1 type II toxin-antitoxin system HicA family toxin Toxin
C163_RS20400 4642033..4643049 + 1017 WP_025340379.1 ligase-associated DNA damage response exonuclease -
C163_RS20405 4643046..4644704 + 1659 WP_025340380.1 ATP-dependent DNA ligase -
C163_RS20410 4644928..4646043 + 1116 WP_025340381.1 succinylglutamate desuccinylase/aspartoacylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6895.01 Da        Isoelectric Point: 11.1658

>T45847 WP_025340378.1 NZ_CP007012:c4641826-4641644 [Pseudomonas sp. FGI182]
MKYSEFRRWLRGQGATFVAAKGSHFKVYLGNRQTIFPDHGAKEISEGLRRKILKDLGLKS

Download         Length: 183 bp

>T45847 NZ_CP007012:c4641826-4641644 [Pseudomonas sp. FGI182]
ATGAAATACAGCGAATTTCGCCGATGGCTGCGCGGCCAAGGCGCTACGTTTGTCGCTGCCAAGGGTAGTCATTTCAAGGT
CTATCTAGGTAATCGCCAGACGATTTTCCCAGATCACGGGGCGAAGGAAATAAGCGAAGGCCTGAGACGGAAGATCCTGA
AGGACCTAGGGTTGAAATCATGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15426.84 Da        Isoelectric Point: 4.7494

>AT45847 WP_038408384.1 NZ_CP007012:c4641623-4641198 [Pseudomonas sp. FGI182]
MVFEYPVVVHLEDGSVWVSCPDVPEMACAGDTSEEALFDAVDALESALSFYVDQKIAIPLPATPTEGQPVVRLPALTAAK
AALWNTMVAQKISKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELSVVAV

Download         Length: 426 bp

>AT45847 NZ_CP007012:c4641623-4641198 [Pseudomonas sp. FGI182]
ATGGTATTCGAATATCCGGTAGTCGTTCATCTGGAAGACGGCAGTGTCTGGGTGAGTTGTCCCGATGTGCCTGAGATGGC
CTGCGCAGGTGACACTTCGGAGGAAGCTCTGTTCGATGCCGTGGATGCCTTGGAGTCCGCACTTTCGTTCTATGTGGATC
AAAAAATAGCTATTCCGCTGCCTGCAACACCAACCGAAGGTCAACCCGTCGTACGTCTGCCAGCCCTGACCGCCGCGAAG
GCAGCGTTGTGGAATACGATGGTTGCACAAAAAATCAGCAAGACCGAGATGGCGCGCCGACTTGGAGTGAATCGTCCCCA
GGTCGATCGTCTGGTCGATCTGCTGCACCGTTCCAAGATCGAGCAGGTCGAGCATGCGCTGCACGTGTTGGGACAGCGGA
TCGAGCTTTCAGTCGTAGCTGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V9X276

Antitoxin

Source ID Structure
AlphaFold DB A0A1L5PZ99

References