Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1546550..1547097 | Replicon | chromosome |
| Accession | NZ_CP007004 | ||
| Organism | Vibrio parahaemolyticus UCM-V493 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | VPUCM_RS07065 | Protein ID | WP_025441737.1 |
| Coordinates | 1546795..1547097 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | VPUCM_RS07060 | Protein ID | WP_005448240.1 |
| Coordinates | 1546550..1546807 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VPUCM_RS24850 | 1542089..1542181 | + | 93 | WP_079390556.1 | DUF3265 domain-containing protein | - |
| VPUCM_RS07030 | 1542215..1542655 | + | 441 | WP_025441732.1 | GNAT family N-acetyltransferase | - |
| VPUCM_RS24855 | 1542664..1542807 | + | 144 | Protein_1391 | DUF3265 domain-containing protein | - |
| VPUCM_RS07035 | 1542823..1543809 | + | 987 | WP_025441733.1 | hypothetical protein | - |
| VPUCM_RS24860 | 1543824..1543916 | + | 93 | WP_079390557.1 | DUF3265 domain-containing protein | - |
| VPUCM_RS07040 | 1543948..1544565 | + | 618 | WP_025441734.1 | hypothetical protein | - |
| VPUCM_RS24865 | 1544580..1544672 | + | 93 | WP_079390558.1 | DUF3265 domain-containing protein | - |
| VPUCM_RS07045 | 1544719..1545300 | + | 582 | WP_140374425.1 | hypothetical protein | - |
| VPUCM_RS24870 | 1545322..1545414 | + | 93 | WP_005448238.1 | DUF3265 domain-containing protein | - |
| VPUCM_RS07050 | 1545443..1545802 | + | 360 | WP_017634597.1 | hypothetical protein | - |
| VPUCM_RS07055 | 1545975..1546346 | + | 372 | WP_025441736.1 | RidA family protein | - |
| VPUCM_RS07060 | 1546550..1546807 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VPUCM_RS07065 | 1546795..1547097 | + | 303 | WP_025441737.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VPUCM_RS07070 | 1547264..1547968 | + | 705 | WP_025441738.1 | potassium channel family protein | - |
| VPUCM_RS07075 | 1548115..1548528 | + | 414 | WP_025441739.1 | hypothetical protein | - |
| VPUCM_RS26915 | 1548715..1549053 | + | 339 | WP_025441740.1 | hypothetical protein | - |
| VPUCM_RS07085 | 1549195..1549641 | + | 447 | WP_025441741.1 | GNAT family N-acetyltransferase | - |
| VPUCM_RS07090 | 1549856..1550071 | + | 216 | WP_005447484.1 | DUF4177 domain-containing protein | - |
| VPUCM_RS24880 | 1550074..1550298 | + | 225 | WP_079390542.1 | membrane protein insertion efficiency factor YidD | - |
| VPUCM_RS07095 | 1550298..1550687 | + | 390 | WP_025441689.1 | membrane protein | - |
| VPUCM_RS07100 | 1550842..1551117 | + | 276 | WP_025441742.1 | hypothetical protein | - |
| VPUCM_RS07105 | 1551223..1551687 | + | 465 | WP_025441743.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | VP1611 | 1427421..1859333 | 431912 | |
| - | inside | Integron | - | - | 1500806..1604512 | 103706 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11695.60 Da Isoelectric Point: 4.8659
>T45843 WP_025441737.1 NZ_CP007004:1546795-1547097 [Vibrio parahaemolyticus UCM-V493]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEYLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEYLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T45843 NZ_CP007004:1546795-1547097 [Vibrio parahaemolyticus UCM-V493]
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAATATTTAAGTTATCGTGAAGTTGTCGTTAACCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAGTAA
ATGGCTGAAATAATCTGGACTGAACCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAATATTTAAGTTATCGTGAAGTTGTCGTTAACCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCCTGTTGAGTAAACAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT45843 WP_005448240.1 NZ_CP007004:1546550-1546807 [Vibrio parahaemolyticus UCM-V493]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT45843 NZ_CP007004:1546550-1546807 [Vibrio parahaemolyticus UCM-V493]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAGCCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCTTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGCCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|