Detailed information of TA system TA045841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): fic-relB/Fic-Fic
• Location: 1243287..1245055
• Replicon: chromosome
• Accession: NZ_CP006999
• Organism: Campylobacter fetus subsp. venerealis cfvi03/293

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: CFVI03293_RS06260
• Protein ID: WP_025370368.1
• Coordinates: 1243287..1244219 (-)
• Length: 311 a.a.

Antitoxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: CFVI03293_RS06265
• Protein ID: WP_025370369.1
• Coordinates: 1244219..1245055 (-)
• Length: 279 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFVI03293_RS06230	1238759..1239151	-	393	WP_025370364.1	hypothetical protein	-
CFVI03293_RS06235	1239293..1239520	-	228	WP_025370365.1	hypothetical protein	-
CFVI03293_RS06240	1239838..1240392	+	555	WP_145916502.1	hypothetical protein	-
CFVI03293_RS06245	1240389..1241729	+	1341	WP_025370366.1	relaxase/mobilization nuclease domain-containing protein	-
CFVI03293_RS06250	1241733..1242998	-	1266	WP_025370367.1	HipA domain-containing protein	-
CFVI03293_RS06255	1243001..1243285	-	285	WP_010401063.1	hypothetical protein	-
CFVI03293_RS06260	1243287..1244219	-	933	WP_025370368.1	Fic family protein	Toxin
CFVI03293_RS06265	1244219..1245055	-	837	WP_025370369.1	Fic family protein	Antitoxin
CFVI03293_RS06270	1245059..1245361	-	303	WP_080582791.1	DUF86 domain-containing protein	-
CFVI03293_RS06275	1245483..1245794	-	312	WP_002850963.1	nucleotidyltransferase domain-containing protein	-
CFVI03293_RS06280	1245862..1246524	-	663	WP_002850964.1	AAA family ATPase	-
CFVI03293_RS06285	1246549..1246866	-	318	WP_010400644.1	hypothetical protein	-
CFVI03293_RS06290	1246934..1247494	-	561	WP_025370370.1	hypothetical protein	-
CFVI03293_RS06295	1247697..1247912	-	216	WP_002850970.1	hypothetical protein	-
CFVI03293_RS06300	1247909..1248163	-	255	WP_010400630.1	hypothetical protein	-
CFVI03293_RS06305	1248160..1249083	-	924	WP_025370371.1	toprim domain-containing protein	-
CFVI03293_RS06310	1249187..1249642	+	456	WP_010404250.1	IS200/IS605 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1230352..1273204	42852
	-	flank	IS/Tn	-	-	1249187..1249642	455

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (91-202)

Antitoxin

• Fido domain-containing protein (12-222)

Sequences

Toxin

Protein

• Length: 311 a.a.
• Molecular weight: 35935.59 Da
• Isoelectric Point: 7.1676

>T45841 WP_025370368.1 NZ_CP006999:c1244219-1243287 [Campylobacter fetus subsp. venerealis cfvi03/293]
MQEQYTEIKDSNIINKQNIDIAVGLGLVDDLKPSEYFYKAVEKSRTYNELEDNVKKYYDGKKLDKKEVGEKECDIVSVNI
AKYLEKSGFTLSPVTLKTIHKNLFWDAFPQGLEKYVGVFRDVNISKKEEVLGGEKSVEYGNYDELGDMLDYDFDREKRKD
YAKMTRQEQALNVGKFVSGVWQIHPFREGNTRTIAVFTIKYLQSKGFEANNDIFKENSKYFRDALVLANYDNMKENIKSD
FSYLESFFNKFILNKNIELKPLPNNQIKEKEQKTSAKSVLERLGDTYFSKLESGAIKEASSNDKSKGKER

Nucleotide

• Length: 933 bp

>T45841 NZ_CP006999:c1244219-1243287 [Campylobacter fetus subsp. venerealis cfvi03/293]
ATGCAAGAACAATATACGGAAATCAAAGATAGCAATATTATTAATAAACAAAACATAGATATTGCAGTAGGGCTTGGGCT
TGTAGATGATCTGAAGCCTTCTGAGTATTTTTATAAGGCTGTTGAAAAATCGCGAACATACAACGAACTTGAAGACAATG
TAAAGAAATATTATGATGGCAAAAAGCTAGATAAAAAAGAGGTCGGCGAAAAAGAGTGCGATATAGTTTCAGTAAATATC
GCCAAGTATTTAGAAAAAAGTGGCTTTACGCTATCTCCTGTTACATTGAAGACTATACATAAAAATTTATTTTGGGATGC
CTTTCCACAAGGGCTTGAAAAATATGTTGGAGTTTTTAGGGATGTAAATATTTCAAAAAAAGAAGAAGTCTTGGGTGGCG
AAAAAAGCGTAGAGTATGGTAATTATGATGAGCTTGGCGATATGCTGGATTATGATTTTGATAGAGAAAAACGCAAAGAT
TACGCCAAAATGACTAGGCAAGAACAGGCTTTAAATGTCGGCAAATTTGTAAGCGGGGTATGGCAAATTCATCCGTTTCG
AGAAGGCAATACTAGGACAATTGCGGTTTTTACTATTAAGTATCTGCAAAGTAAAGGCTTTGAAGCAAACAACGATATCT
TTAAAGAAAACTCAAAATATTTCAGGGATGCTTTAGTGTTAGCAAATTACGACAATATGAAAGAAAATATAAAAAGTGAT
TTTTCATACCTAGAGAGTTTTTTTAACAAATTTATTCTAAATAAAAATATAGAACTAAAACCATTGCCAAATAATCAAAT
AAAAGAAAAAGAACAAAAAACTAGTGCAAAATCTGTCCTTGAAAGACTTGGCGATACGTATTTTTCAAAGTTAGAGAGCG
GAGCAATAAAAGAAGCAAGCAGCAATGACAAATCAAAGGGCAAGGAACGATAA

Antitoxin

Protein

• Length: 279 a.a.
• Molecular weight: 31825.25 Da
• Isoelectric Point: 8.5962

>AT45841 WP_025370369.1 NZ_CP006999:c1245055-1244219 [Campylobacter fetus subsp. venerealis cfvi03/293]
MDGGVNLGNFLKNNNERDYWLDVCVRMAHHSTAIEGNTLSQDETASILLDGYIAKATSEREFYEVKNYRQISPKMFSSLQ
EKAKIDEKLIKDFHRLIMNNLIDNNGKFKTIENLVVGANFEPTKPYLVPVAIKDMCDNLYFRLDNAKNDDDKLKAILQSH
IKFEKIHPFSDGNGRTGRIIMIYGCLENNLAPIIIPKEQKNRYIAILRNNDIDGFMAFAKEIEKDEISRRNKFLSQRPNE
QDNSKSVLSRLGNAYAKKLESGAIKALNDTANSKEKER

Nucleotide

• Length: 837 bp

>AT45841 NZ_CP006999:c1245055-1244219 [Campylobacter fetus subsp. venerealis cfvi03/293]
ATGGATGGCGGTGTAAATTTAGGCAATTTCTTAAAAAACAACAACGAGCGAGACTATTGGCTAGATGTATGTGTTCGTAT
GGCTCATCATAGCACAGCAATCGAGGGCAATACTTTAAGTCAGGATGAGACTGCTTCAATCTTGCTTGATGGCTATATAG
CAAAAGCAACTAGCGAGCGTGAATTTTATGAAGTAAAAAACTATCGCCAAATTTCGCCAAAAATGTTTTCATCTTTACAA
GAAAAAGCCAAGATAGACGAGAAGCTAATAAAAGATTTTCATAGGCTAATAATGAATAATTTAATAGACAACAACGGCAA
ATTTAAAACTATCGAAAATTTAGTTGTAGGCGCAAATTTCGAACCTACAAAGCCGTATCTAGTGCCAGTAGCAATTAAAG
ATATGTGCGATAATCTATATTTTAGACTTGATAATGCCAAAAATGACGACGATAAGCTAAAAGCAATATTGCAAAGCCAT
ATCAAATTTGAAAAAATTCATCCTTTTAGTGACGGAAACGGCAGAACCGGCAGGATAATTATGATCTATGGTTGTTTAGA
GAATAATTTAGCACCAATTATAATACCAAAAGAGCAAAAAAATAGATACATTGCAATACTGCGCAACAATGACATCGATG
GATTTATGGCGTTTGCTAAAGAAATAGAAAAAGATGAAATATCAAGGCGTAATAAATTTTTAAGCCAACGACCAAATGAG
CAAGATAATAGTAAATCAGTCTTATCTAGGCTCGGCAATGCTTACGCCAAAAAGCTAGAAAGCGGAGCGATCAAAGCATT
AAATGATACCGCAAATTCAAAGGAAAAGGAGAGATAA