Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3035276..3035949 Replicon chromosome
Accession NZ_CP006986
Organism Rhizobium sp. IE4771

Toxin (Protein)


Gene name vapC Uniprot ID A0A060I875
Locus tag IE4771_RS14860 Protein ID WP_038690080.1
Coordinates 3035276..3035689 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A060I987
Locus tag IE4771_RS14865 Protein ID WP_010061195.1
Coordinates 3035686..3035949 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4771_RS14850 3032768..3033967 - 1200 WP_038690079.1 efflux RND transporter periplasmic adaptor subunit -
IE4771_RS14855 3034242..3035153 - 912 WP_010061191.1 adenylate/guanylate cyclase domain-containing protein -
IE4771_RS14860 3035276..3035689 - 414 WP_038690080.1 type II toxin-antitoxin system VapC family toxin Toxin
IE4771_RS14865 3035686..3035949 - 264 WP_010061195.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IE4771_RS14870 3036028..3037578 - 1551 WP_038690082.1 SpoVR family protein -
IE4771_RS14875 3037575..3038849 - 1275 WP_038690084.1 YeaH/YhbH family protein -
IE4771_RS14880 3038862..3040805 - 1944 WP_038690085.1 PrkA family serine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-57)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15161.62 Da        Isoelectric Point: 7.2779

>T45835 WP_038690080.1 NZ_CP006986:c3035689-3035276 [Rhizobium sp. IE4771]
MTAWMLDTNIASHVIKGDRPEILKRLATLPMDEIVISSITEGELLYGLAKRGYPKALSERVRQFLLRVDVLPWDHDVTRT
YGDLRAACEAKGTILAPLDMMIAAHAVATAATLVTRDKAFARISEPLKVDDWTGGRS

Download         Length: 414 bp

>T45835 NZ_CP006986:c3035689-3035276 [Rhizobium sp. IE4771]
ATGACGGCATGGATGCTCGACACCAATATCGCCAGTCATGTCATTAAAGGCGATCGGCCGGAGATACTTAAAAGACTGGC
GACGCTTCCAATGGACGAGATCGTCATCTCATCGATCACGGAAGGGGAATTGCTCTACGGTCTTGCCAAGCGAGGCTATC
CGAAGGCGCTATCCGAGCGGGTAAGGCAATTCCTTCTCAGGGTCGATGTTCTCCCCTGGGATCACGACGTCACGCGAACC
TATGGTGACCTGCGCGCCGCCTGTGAAGCCAAAGGCACGATTCTGGCGCCCCTGGACATGATGATTGCCGCTCATGCCGT
CGCGACCGCGGCAACCCTCGTCACGCGTGACAAGGCTTTTGCTCGCATTTCTGAGCCTTTAAAGGTCGATGACTGGACGG
GCGGAAGAAGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10119.33 Da        Isoelectric Point: 5.8867

>AT45835 WP_010061195.1 NZ_CP006986:c3035949-3035686 [Rhizobium sp. IE4771]
MATKTAKIFTTGRSQAVRLPAEFRFEESEVFVRRDPKTGDVILSRKPDSWDGLFELHRKDPIPDDFLGPADRRQPSQDRD
PFEGWKE

Download         Length: 264 bp

>AT45835 NZ_CP006986:c3035949-3035686 [Rhizobium sp. IE4771]
ATGGCAACGAAAACGGCTAAGATTTTTACGACCGGCCGCAGCCAGGCGGTGAGGCTCCCTGCGGAGTTTCGCTTTGAAGA
GAGCGAAGTGTTCGTTCGTCGTGATCCGAAGACCGGTGATGTCATATTATCGCGCAAGCCGGATTCATGGGATGGCCTTT
TCGAACTCCATCGGAAGGATCCGATTCCGGACGATTTCCTTGGACCGGCCGATCGTCGCCAACCTTCGCAAGATCGTGAT
CCGTTCGAAGGTTGGAAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060I875

Antitoxin

Source ID Structure
AlphaFold DB A0A060I987

References