Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 871268..871986 Replicon chromosome
Accession NZ_CP006986
Organism Rhizobium sp. IE4771

Toxin (Protein)


Gene name vapC Uniprot ID A0A060I294
Locus tag IE4771_RS04205 Protein ID WP_038687107.1
Coordinates 871268..871726 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A060I3H0
Locus tag IE4771_RS04210 Protein ID WP_009996202.1
Coordinates 871723..871986 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4771_RS04185 867053..868690 - 1638 WP_038687103.1 chaperonin GroEL -
IE4771_RS04190 868762..869058 - 297 WP_004675403.1 co-chaperone GroES -
IE4771_RS04195 869394..870242 + 849 WP_038687105.1 TIGR01459 family HAD-type hydrolase -
IE4771_RS04200 870257..871240 + 984 WP_038692264.1 bifunctional riboflavin kinase/FAD synthetase -
IE4771_RS04205 871268..871726 - 459 WP_038687107.1 type II toxin-antitoxin system VapC family toxin Toxin
IE4771_RS04210 871723..871986 - 264 WP_009996202.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IE4771_RS04215 872340..875246 + 2907 WP_038687109.1 isoleucine--tRNA ligase -
IE4771_RS04220 875378..876007 + 630 WP_038687111.1 hypothetical protein -
IE4771_RS04225 876293..876730 - 438 WP_038687113.1 nucleoside deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(7-58)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17027.15 Da        Isoelectric Point: 6.2350

>T45834 WP_038687107.1 NZ_CP006986:c871726-871268 [Rhizobium sp. IE4771]
VIGWLLDTNVIAALINPNGAPSVKSWAAAQDENQMFISVLTLAEYDKGIENLPEDDRNRYRYIAARDALEERFSQRTLSL
SDAGVRHWGAISGRTKLRTGHTPPVIDTMLTATAIEHNLYLVTRNVKDTRFSGAAVFDPWTNDPDQFPLSRK

Download         Length: 459 bp

>T45834 NZ_CP006986:c871726-871268 [Rhizobium sp. IE4771]
GTGATCGGATGGCTGCTCGACACCAACGTCATTGCGGCGCTGATCAATCCGAACGGCGCGCCCTCCGTGAAGTCCTGGGC
TGCCGCGCAGGACGAGAACCAGATGTTCATTAGCGTGCTCACCCTCGCAGAATATGACAAAGGCATCGAAAACCTGCCTG
AAGACGACCGGAACCGCTATCGCTATATAGCGGCGCGCGACGCTCTGGAGGAGCGGTTCTCACAGCGTACTCTCTCGCTG
AGCGACGCGGGCGTCAGGCATTGGGGTGCTATTTCAGGGCGCACAAAACTGCGAACCGGACATACGCCGCCGGTCATCGA
CACGATGCTGACCGCCACCGCCATCGAGCACAATCTCTATCTGGTGACGCGAAACGTAAAGGATACGCGCTTCTCCGGCG
CGGCAGTCTTCGATCCGTGGACAAACGATCCGGATCAATTCCCATTGAGCCGGAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10124.70 Da        Isoelectric Point: 8.5600

>AT45834 WP_009996202.1 NZ_CP006986:c871986-871723 [Rhizobium sp. IE4771]
MRKVIKQSWKLEDAKARFSEVVRRARSEGPQRVTVRGKDSVVIISVEELERLTKAEPKKPLVDFMESLALKELDLEREPD
YGRDVEL

Download         Length: 264 bp

>AT45834 NZ_CP006986:c871986-871723 [Rhizobium sp. IE4771]
ATGAGAAAAGTCATTAAGCAAAGCTGGAAGCTCGAGGACGCCAAAGCGCGCTTCAGCGAAGTCGTGCGCCGTGCCCGCAG
CGAAGGGCCACAGCGCGTCACAGTGCGCGGCAAAGACAGCGTCGTCATCATCAGCGTCGAAGAACTCGAACGGTTGACGA
AGGCCGAGCCCAAAAAGCCCCTGGTCGACTTCATGGAGAGCCTCGCTCTGAAAGAGCTCGATCTGGAGCGGGAGCCCGAT
TACGGGCGGGACGTCGAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060I294

Antitoxin

Source ID Structure
AlphaFold DB A0A060I3H0

References