Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 375651..376288 Replicon chromosome
Accession NZ_CP006986
Organism Rhizobium sp. IE4771

Toxin (Protein)


Gene name vapC Uniprot ID A0A060HRP4
Locus tag IE4771_RS01865 Protein ID WP_010047998.1
Coordinates 375651..376049 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A060HVL6
Locus tag IE4771_RS01870 Protein ID WP_038686430.1
Coordinates 376046..376288 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4771_RS01840 370913..371725 + 813 WP_038692173.1 class II glutamine amidotransferase -
IE4771_RS01845 371712..372923 - 1212 WP_038686422.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
IE4771_RS01850 373023..373904 - 882 WP_038686424.1 LysR family transcriptional regulator -
IE4771_RS01855 373996..375246 + 1251 WP_038686427.1 MFS transporter -
IE4771_RS01860 375243..375629 + 387 WP_010048003.1 VOC family protein -
IE4771_RS01865 375651..376049 - 399 WP_010047998.1 type II toxin-antitoxin system VapC family toxin Toxin
IE4771_RS01870 376046..376288 - 243 WP_038686430.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IE4771_RS01875 376342..378003 - 1662 WP_038686431.1 urocanate hydratase -
IE4771_RS01880 378239..378568 - 330 WP_010050285.1 TfoX/Sxy family protein -
IE4771_RS01885 378572..379669 - 1098 WP_038686433.1 DUF917 domain-containing protein -
IE4771_RS01890 379650..380930 - 1281 WP_038686435.1 Zn-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14686.83 Da        Isoelectric Point: 6.2354

>T45833 WP_010047998.1 NZ_CP006986:c376049-375651 [Rhizobium sp. IE4771]
MKYLLDTNAVIALIKGNDRLIAELRKHTPTDFAMPAIVAHELFYGAYKSLHIDENLARIDALQFAILEFDRNDARRAGEV
RAALRASGTPIGPYDVLIAGQAAARGLVLITRNLREFERVADLQVENWEGSP

Download         Length: 399 bp

>T45833 NZ_CP006986:c376049-375651 [Rhizobium sp. IE4771]
ATGAAGTACCTGCTCGATACTAATGCCGTCATTGCCTTGATAAAGGGCAATGACCGCCTCATCGCCGAACTGCGCAAGCA
CACACCAACGGATTTCGCCATGCCGGCGATCGTCGCGCATGAACTCTTTTACGGCGCTTACAAAAGTTTGCATATCGATG
AGAATCTGGCGCGGATCGATGCGCTACAATTCGCCATACTGGAATTTGACCGGAACGACGCGCGCAGGGCCGGAGAAGTT
CGCGCAGCGCTGCGAGCATCGGGAACGCCCATCGGCCCCTATGACGTCCTGATTGCCGGGCAGGCCGCTGCGCGCGGCCT
CGTCCTGATCACCCGCAATCTGAGGGAGTTCGAGCGCGTGGCGGACCTGCAGGTAGAGAATTGGGAAGGCTCGCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9179.25 Da        Isoelectric Point: 4.3063

>AT45833 WP_038686430.1 NZ_CP006986:c376288-376046 [Rhizobium sp. IE4771]
METAKIFWSGRSQAVRLPKEFRFDGDSVTIRRQGRAIVLEPISDNWDWLADVIGPVDPDFATAAEEQPAQQERPDLDFFK

Download         Length: 243 bp

>AT45833 NZ_CP006986:c376288-376046 [Rhizobium sp. IE4771]
ATGGAAACCGCAAAAATCTTCTGGTCAGGGCGTTCGCAAGCCGTCCGCTTGCCGAAGGAATTCCGCTTTGATGGCGATAG
TGTCACCATCCGGCGCCAAGGGCGTGCGATCGTCCTCGAACCGATTTCCGACAATTGGGATTGGCTGGCTGACGTGATCG
GTCCGGTCGATCCCGACTTCGCGACAGCAGCAGAAGAGCAGCCTGCGCAACAGGAACGACCTGACCTCGACTTCTTCAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HRP4

Antitoxin

Source ID Structure
AlphaFold DB A0A060HVL6

References