Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 213555..214099 Replicon chromosome
Accession NZ_CP006986
Organism Rhizobium sp. IE4771

Toxin (Protein)


Gene name parE Uniprot ID A0A060HUX9
Locus tag IE4771_RS01005 Protein ID WP_010057835.1
Coordinates 213809..214099 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060I1L4
Locus tag IE4771_RS01000 Protein ID WP_038686168.1
Coordinates 213555..213806 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4771_RS00975 209576..210535 + 960 WP_038686164.1 glyoxylate/hydroxypyruvate reductase A -
IE4771_RS00980 210735..211115 + 381 WP_009982537.1 hypothetical protein -
IE4771_RS00985 211282..212586 + 1305 WP_004673542.1 nicotinate phosphoribosyltransferase -
IE4771_RS00990 212583..212807 - 225 WP_010057833.1 hypothetical protein -
IE4771_RS00995 213134..213343 - 210 WP_009994618.1 KTSC domain-containing protein -
IE4771_RS01000 213555..213806 + 252 WP_038686168.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IE4771_RS01005 213809..214099 + 291 WP_010057835.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE4771_RS01015 214448..214765 + 318 WP_038686170.1 hypothetical protein -
IE4771_RS34690 214825..215022 - 198 WP_186007833.1 hypothetical protein -
IE4771_RS01020 215179..216171 + 993 WP_038686172.1 BMP family ABC transporter substrate-binding protein -
IE4771_RS01025 216260..217771 + 1512 WP_038686174.1 ABC transporter ATP-binding protein -
IE4771_RS01030 217779..218882 + 1104 WP_038686176.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(3-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10988.53 Da        Isoelectric Point: 6.8495

>T45832 WP_010057835.1 NZ_CP006986:213809-214099 [Rhizobium sp. IE4771]
MGFRLTEEAEEDIVGIAETGIRLFGSAHARRYHDELYAIFNLIAANPRMARERHEISPPMRIHPFKAHLVVYTIAEGGNV
LIVRIRHGHEDWSSQV

Download         Length: 291 bp

>T45832 NZ_CP006986:213809-214099 [Rhizobium sp. IE4771]
ATGGGCTTTCGCCTTACGGAAGAAGCGGAAGAGGACATTGTCGGCATAGCCGAAACGGGCATTCGCCTGTTTGGCTCAGC
GCACGCTCGGCGCTACCATGATGAACTCTACGCCATTTTTAATCTGATTGCTGCCAATCCCCGTATGGCGCGCGAACGGC
ATGAAATTTCTCCTCCGATGCGCATTCATCCGTTCAAGGCCCATCTCGTCGTTTATACGATTGCGGAGGGCGGTAATGTT
CTCATTGTCCGTATTCGCCACGGACACGAAGATTGGTCCAGTCAGGTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9352.44 Da        Isoelectric Point: 8.5309

>AT45832 WP_038686168.1 NZ_CP006986:213555-213806 [Rhizobium sp. IE4771]
MATMNVSLPDPMKDWVEAQTKTGRYANASDYVRDLIRKDQERNDKVAAMQRFVDEGLKSGVGSRSKDELFEAARARVESS
RGN

Download         Length: 252 bp

>AT45832 NZ_CP006986:213555-213806 [Rhizobium sp. IE4771]
ATGGCGACCATGAACGTATCGCTGCCCGATCCCATGAAAGATTGGGTGGAAGCGCAAACCAAAACAGGCCGTTATGCCAA
TGCGAGCGATTATGTCCGCGACCTCATCAGGAAAGATCAGGAGCGAAACGACAAGGTCGCAGCTATGCAGCGCTTTGTCG
ATGAAGGCTTGAAGAGCGGCGTCGGGTCGCGGTCGAAGGACGAGCTGTTTGAGGCGGCGCGGGCGCGCGTGGAAAGCTCT
CGCGGCAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HUX9

Antitoxin

Source ID Structure
AlphaFold DB A0A060I1L4

References