Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 735806..736328 Replicon chromosome
Accession NZ_CP006957
Organism Mannheimia haemolytica USDA-ARS-USMARC-184

Toxin (Protein)


Gene name - Uniprot ID A0A249A107
Locus tag B824_RS03830 Protein ID WP_006249269.1
Coordinates 735806..736102 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A249A190
Locus tag B824_RS03835 Protein ID WP_006249270.1
Coordinates 736086..736328 (+) Length 81 a.a.

Genomic Context

B824_RS03815B824_RS03820B824_RS03825B824_RS03830B824_RS03835B824_RS03840B824_RS03850B824_RS03855B824_RS03860B824_RS03845
Location: 730860..732185 (1326 bp)
Type: Others
Protein ID: WP_020831251.1
Location: 732306..732605 (300 bp)
Type: Others
Protein ID: WP_006249265.1
Location: 732767..735679 (2913 bp)
Type: Others
Protein ID: WP_006249267.1
Location: 735806..736102 (297 bp)
Type: Toxin
Protein ID: WP_006249269.1
Location: 736086..736328 (243 bp)
Type: Antitoxin
Protein ID: WP_006249270.1
Location: 736340..737008 (669 bp)
Type: Others
Protein ID: WP_006249271.1
Location: 737621..738463 (843 bp)
Type: Others
Protein ID: WP_006250575.1
Location: 738586..739227 (642 bp)
Type: Others
Protein ID: WP_040080687.1
Location: 739401..740478 (1078 bp)
Type: Others
Protein ID: Protein_698
Location: 736986..737561 (576 bp)
Type: Others
Protein ID: WP_006249272.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B824_RS03815730860..732185+1326WP_020831251.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
B824_RS03820732306..732605+300WP_006249265.1hypothetical protein-
B824_RS03825732767..735679+2913WP_006249267.1RNA polymerase-associated protein RapA-
B824_RS03830735806..736102+297WP_006249269.1BrnT family toxinToxin
B824_RS03835736086..736328+243WP_006249270.1CopG family transcriptional regulatorAntitoxin
B824_RS03840736340..737008+669WP_006249271.1bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA-
B824_RS03845736986..737561-576WP_006249272.11,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD-
B824_RS03850737621..738463+843WP_006250575.123S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ-
B824_RS03855738586..739227+642WP_040080687.1orotate phosphoribosyltransferase-
B824_RS03860739401..740478+1078Protein_6985-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(15-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 12009.89 Da        Isoelectric Point: 7.9454

>T45825 WP_006249269.1 NZ_CP006957:735806-736102 [Mannheimia haemolytica USDA-ARS-USMARC-184]
MYIDLQYAVPLLFEYDPNKSQINLAKYGIDFEQAKLLWEDERKVVLEACIEPELRYFLIGKIYDKYWTAFFTPRNDVIRL
ISVRRSRKKEISYYEKYH

Download         Length: 297 bp

>T45825 NZ_CP006957:735806-736102 [Mannheimia haemolytica USDA-ARS-USMARC-184]
ATGTATATAGATTTGCAATATGCTGTGCCGTTATTGTTTGAATACGACCCGAACAAAAGCCAAATTAATTTAGCCAAATA
TGGTATTGATTTTGAACAGGCAAAGTTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAAT
TACGCTATTTCCTGATTGGCAAGATTTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTA
ATTTCAGTTAGACGTTCCCGTAAAAAAGAGATCTCATACTATGAGAAATACCATTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9346.79 Da        Isoelectric Point: 7.1665

>AT45825 WP_006249270.1 NZ_CP006957:736086-736328 [Mannheimia haemolytica USDA-ARS-USMARC-184]
MRNTISAEELERIFDEGKEDILQYCDLSTAHRPGQMKRVNVDFPNWMVEALDKQARHLGVPRQALIKMWIAEKLPVQSPR

Download         Length: 243 bp

>AT45825 NZ_CP006957:736086-736328 [Mannheimia haemolytica USDA-ARS-USMARC-184]
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGATTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A249A107

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A249A190

References