Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 309625..310147 Replicon chromosome
Accession NZ_CP006957
Organism Mannheimia haemolytica USDA-ARS-USMARC-184

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag B824_RS01600 Protein ID WP_040080572.1
Coordinates 309625..309894 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A248ZY54
Locus tag B824_RS01605 Protein ID WP_006250323.1
Coordinates 309881..310147 (-) Length 89 a.a.

Genomic Context

B824_RS01595B824_RS01610B824_RS01615B824_RS01620B824_RS01630B824_RS01580B824_RS01585B824_RS01590B824_RS01600B824_RS01605
Location: 307723..309606 (1884 bp)
Type: Others
Protein ID: WP_040080571.1
Location: 310587..311540 (954 bp)
Type: Others
Protein ID: WP_040080573.1
Location: 311609..311881 (273 bp)
Type: Others
Protein ID: WP_006250326.1
Location: 311901..313286 (1386 bp)
Type: Others
Protein ID: WP_006251981.1
Location: 313624..314664 (1041 bp)
Type: Others
Protein ID: WP_040080511.1
Location: 304945..305379 (435 bp)
Type: Others
Protein ID: WP_006250318.1
Location: 305354..306199 (846 bp)
Type: Others
Protein ID: WP_006251985.1
Location: 306201..307439 (1239 bp)
Type: Others
Protein ID: WP_006251984.1
Location: 309625..309894 (270 bp)
Type: Toxin
Protein ID: WP_040080572.1
Location: 309881..310147 (267 bp)
Type: Antitoxin
Protein ID: WP_006250323.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
B824_RS01580304945..305379-435WP_006250318.1D-tyrosyl-tRNA(Tyr) deacylase-
B824_RS01585305354..306199-846WP_006251985.1virulence factor BrkB family protein-
B824_RS01590306201..307439-1239WP_006251984.1glutamate-5-semialdehyde dehydrogenase-
B824_RS01595307723..309606+1884WP_040080571.1DNA mismatch repair endonuclease MutL-
B824_RS01600309625..309894-270WP_040080572.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
B824_RS01605309881..310147-267WP_006250323.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
B824_RS01610310587..311540+954WP_040080573.1tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA-
B824_RS01615311609..311881+273WP_006250326.1RNA chaperone Hfq-
B824_RS01620311901..313286+1386WP_006251981.1GTPase HflX-
B824_RS01630313624..314664+1041WP_040080511.1IS481 family transposase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10508.09 Da        Isoelectric Point: 6.4732

>T45824 WP_040080572.1 NZ_CP006957:c309894-309625 [Mannheimia haemolytica USDA-ARS-USMARC-184]
MREIEYSNAFKRDYKKCAVEFLSSSLIEALYFLINDKPLPEKYCDHALTGEWKGFRDCHIQPDLVLIYRKVEDDKLELLR
IGSHSHLFG

Download         Length: 270 bp

>T45824 NZ_CP006957:c309894-309625 [Mannheimia haemolytica USDA-ARS-USMARC-184]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTTTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GCTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9738.10 Da        Isoelectric Point: 4.7954

>AT45824 WP_006250323.1 NZ_CP006957:c310147-309881 [Mannheimia haemolytica USDA-ARS-USMARC-184]
MANSALVSVRISPEIKEQASEVLAGIGLTVSDVMRMTLAKIATEKRFQFDYQPNFETAEVLRAVKNGEEKLHSANSIADL
MEQLNARD

Download         Length: 267 bp

>AT45824 NZ_CP006957:c310147-309881 [Mannheimia haemolytica USDA-ARS-USMARC-184]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
No matching records found

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A248ZY54

References