45801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2425406..2427128 Replicon chromosome
Accession NZ_CP006947
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name mosT Uniprot ID D0FZT9
Locus tag N900_RS11080 Protein ID WP_000356587.1
Coordinates 2425406..2426344 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1U9VYW4
Locus tag N900_RS11085 Protein ID WP_000095578.1
Coordinates 2426337..2427128 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N900_RS11060 2421347..2421859 - 513 WP_001166558.1 S26 family signal peptidase -
N900_RS11065 2421843..2422190 - 348 WP_001044650.1 hypothetical protein -
N900_RS11070 2422183..2424582 - 2400 WP_000648042.1 type IV secretion system protein TraC -
N900_RS11075 2424582..2425274 - 693 WP_001228926.1 DsbC family protein -
N900_RS11080 2425406..2426344 - 939 WP_000356587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
N900_RS11085 2426337..2427128 - 792 WP_000095578.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
N900_RS11090 2427349..2427735 - 387 WP_000180223.1 hypothetical protein -
N900_RS11095 2427732..2428304 - 573 WP_001944091.1 type IV conjugative transfer system lipoprotein TraV -
N900_RS11100 2428379..2429668 - 1290 WP_000647305.1 TraB/VirB10 family protein -
N900_RS11105 2429671..2430567 - 897 WP_001911237.1 type-F conjugative transfer system secretin TraK -
N900_RS11110 2430551..2431177 - 627 WP_000667170.1 hypothetical protein -
N900_RS11115 2431174..2431455 - 282 WP_000433891.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element dfrA1 / sul2 / aph(3'')-Ib / aph(6)-Id / floR - 2338447..2486176 147729


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35548.82 Da        Isoelectric Point: 4.9081

>T45801 WP_000356587.1 NZ_CP006947:c2426344-2425406 [Vibrio cholerae O1 str. KW3]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T45801 NZ_CP006947:c2426344-2425406 [Vibrio cholerae O1 str. KW3]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30095.47 Da        Isoelectric Point: 9.5097

>AT45801 WP_000095578.1 NZ_CP006947:c2427128-2426337 [Vibrio cholerae O1 str. KW3]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT45801 NZ_CP006947:c2427128-2426337 [Vibrio cholerae O1 str. KW3]
ATGTCATCTAAAATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTCCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTGCAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAAAATTGGTTTTACTGCGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTTAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCGTAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VZ44

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VYW4

References