Detailed information of TA system TA045793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1830889..1831434
• Replicon: chromosome
• Accession: NZ_CP006942
• Organism: Mannheimia sp. USDA-ARS-USMARC-1261

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W0Q5X9
• Locus tag: X781_RS08830
• Protein ID: WP_025236520.1
• Coordinates: 1831147..1831434 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W0Q7U6
• Locus tag: X781_RS08825
• Protein ID: WP_025236519.1
• Coordinates: 1830889..1831137 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X781_RS08805	1825989..1826462	-	474	WP_025216824.1	xanthine phosphoribosyltransferase	-
X781_RS08810	1826609..1828018	-	1410	WP_025236516.1	DUF560 domain-containing protein	-
X781_RS08815	1828099..1829115	-	1017	WP_025236517.1	hypothetical protein	-
X781_RS08820	1829330..1830784	+	1455	WP_025236518.1	aminoacyl-histidine dipeptidase	-
X781_RS08825	1830889..1831137	+	249	WP_025236519.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
X781_RS08830	1831147..1831434	+	288	WP_025236520.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
X781_RS08835	1831520..1832476	-	957	WP_025236521.1	lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase	-
X781_RS08840	1832854..1833537	-	684	WP_025236522.1	electron transport complex subunit E	-
X781_RS08845	1833546..1834178	-	633	WP_025236523.1	electron transport complex subunit RsxG	-
X781_RS08850	1834178..1835233	-	1056	WP_025236524.1	electron transport complex subunit RsxD	-
X781_RS08855	1835273..1835908	-	636	WP_025236525.1	trimeric intracellular cation channel family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11160.98 Da
• Isoelectric Point: 9.3522

>T45793 WP_025236520.1 NZ_CP006942:1831147-1831434 [Mannheimia sp. USDA-ARS-USMARC-1261]
MVYSIKVHEDFVAELNKLDPTIKQQLRKKLDNVIENPHIPKNRLSGELHNCYKIKLRKAGVRLVYQVNDDEIYILLLTVG
KREDNEVYDTALKRV

Nucleotide

• Length: 288 bp

>T45793 NZ_CP006942:1831147-1831434 [Mannheimia sp. USDA-ARS-USMARC-1261]
ATGGTTTATTCTATTAAAGTTCACGAAGATTTTGTGGCAGAACTAAATAAACTTGATCCTACTATTAAGCAACAACTACG
TAAAAAACTAGATAATGTCATTGAAAATCCTCATATTCCCAAGAATCGCTTAAGTGGCGAACTGCATAATTGCTACAAAA
TCAAATTAAGAAAAGCAGGTGTTCGGCTTGTTTATCAGGTTAATGATGATGAAATCTATATTTTATTACTGACAGTTGGC
AAACGTGAAGATAATGAAGTATATGATACAGCGTTAAAACGAGTGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9313.70 Da
• Isoelectric Point: 5.0323

>AT45793 WP_025236519.1 NZ_CP006942:1830889-1831137 [Mannheimia sp. USDA-ARS-USMARC-1261]
MANLNIRIDDNVKQRAFLAFDNLGISPSDAIRTFLAYVADTGKMPIKQIIVSDEDAQLYNIVKKRLNEPEKIKNTTLDEL
FS

Nucleotide

• Length: 249 bp

>AT45793 NZ_CP006942:1830889-1831137 [Mannheimia sp. USDA-ARS-USMARC-1261]
ATGGCAAACTTGAATATTCGTATTGACGATAATGTTAAGCAACGAGCCTTTTTAGCTTTCGATAATTTGGGCATTAGCCC
ATCGGATGCTATCCGTACATTTTTAGCTTATGTAGCAGATACAGGTAAAATGCCGATTAAGCAAATTATTGTTTCAGATG
AAGATGCCCAATTGTATAACATCGTGAAGAAAAGACTAAATGAACCAGAAAAAATCAAAAATACGACACTCGATGAGCTA
TTTTCATAA

Structures

Toxin

• AlphaFold DB: W0Q5X9

Antitoxin

• AlphaFold DB: W0Q7U6