Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2861582..2862135 Replicon chromosome
Accession NZ_CP006929
Organism Dickeya zeae EC1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag W909_RS12685 Protein ID WP_016941020.1
Coordinates 2861582..2861896 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag W909_RS12690 Protein ID WP_016941021.1
Coordinates 2861899..2862135 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W909_RS12660 2857085..2857831 + 747 WP_016941015.1 hypothetical protein -
W909_RS12665 2858031..2858783 + 753 WP_016941016.1 hypothetical protein -
W909_RS12670 2858945..2859730 - 786 WP_029456302.1 hypothetical protein -
W909_RS12675 2859925..2860275 - 351 Protein_2500 transposase -
W909_RS12680 2860477..2861376 + 900 WP_016941019.1 AraC family transcriptional regulator -
W909_RS12685 2861582..2861896 - 315 WP_016941020.1 CcdB family protein Toxin
W909_RS12690 2861899..2862135 - 237 WP_016941021.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
W909_RS12695 2862456..2863400 - 945 WP_029456303.1 DUF1738 domain-containing protein -
W909_RS12700 2863931..2865805 + 1875 WP_016941023.1 KAP family P-loop domain protein -
W909_RS12705 2866005..2866607 + 603 WP_202799863.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - hcp 2826399..2870902 44503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11500.43 Da        Isoelectric Point: 7.9859

>T45786 WP_016941020.1 NZ_CP006929:c2861896-2861582 [Dickeya zeae EC1]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAIDFLIDGI

Download         Length: 315 bp

>T45786 NZ_CP006929:c2861896-2861582 [Dickeya zeae EC1]
ATGCAATTCACTGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTATTGCTTGATGTCACGAGCGATATTATTGG
GCAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGTCGCCGACCGGATCGCCTTGTCC
CTGTCGTCAGGCTAACGGACGGCAAAGAATACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTGTGCAGGCGCTGGGT
GCGGTGTTCTGTGATGCATCGCAGTACCGTAATCAGGTAAAGGCCGCCATCGATTTCCTTATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9039.06 Da        Isoelectric Point: 5.8500

>AT45786 WP_016941021.1 NZ_CP006929:c2862135-2861899 [Dickeya zeae EC1]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT45786 NZ_CP006929:c2862135-2861899 [Dickeya zeae EC1]
ATGACAGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGAGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAATCTGAGTGCCACGCTGTCAACCGCACTGGATGCGGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAAAACGGCTGTTTCAGTGATGAATACAGGACCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References