Detailed information of TA system TA045786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2861582..2862135
• Replicon: chromosome
• Accession: NZ_CP006929
• Organism: Dickeya zeae EC1

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: W909_RS12685
• Protein ID: WP_016941020.1
• Coordinates: 2861582..2861896 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: W909_RS12690
• Protein ID: WP_016941021.1
• Coordinates: 2861899..2862135 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W909_RS12660	2857085..2857831	+	747	WP_016941015.1	hypothetical protein	-
W909_RS12665	2858031..2858783	+	753	WP_016941016.1	hypothetical protein	-
W909_RS12670	2858945..2859730	-	786	WP_029456302.1	hypothetical protein	-
W909_RS12675	2859925..2860275	-	351	Protein_2500	transposase	-
W909_RS12680	2860477..2861376	+	900	WP_016941019.1	AraC family transcriptional regulator	-
W909_RS12685	2861582..2861896	-	315	WP_016941020.1	CcdB family protein	Toxin
W909_RS12690	2861899..2862135	-	237	WP_016941021.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
W909_RS12695	2862456..2863400	-	945	WP_029456303.1	DUF1738 domain-containing protein	-
W909_RS12700	2863931..2865805	+	1875	WP_016941023.1	KAP family P-loop domain protein	-
W909_RS12705	2866005..2866607	+	603	WP_202799863.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp	2826399..2870902	44503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11500.43 Da
• Isoelectric Point: 7.9859

>T45786 WP_016941020.1 NZ_CP006929:c2861896-2861582 [Dickeya zeae EC1]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T45786 NZ_CP006929:c2861896-2861582 [Dickeya zeae EC1]
ATGCAATTCACTGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTATTGCTTGATGTCACGAGCGATATTATTGG
GCAGTTGAATCGTCGGATAGTGATCCCGTTGCTCCCTGTTGAAAAGTACCCGGCAGGTCGCCGACCGGATCGCCTTGTCC
CTGTCGTCAGGCTAACGGACGGCAAAGAATACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTGTGCAGGCGCTGGGT
GCGGTGTTCTGTGATGCATCGCAGTACCGTAATCAGGTAAAGGCCGCCATCGATTTCCTTATTGACGGCATTTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9039.06 Da
• Isoelectric Point: 5.8500

>AT45786 WP_016941021.1 NZ_CP006929:c2862135-2861899 [Dickeya zeae EC1]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRYEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT45786 NZ_CP006929:c2862135-2861899 [Dickeya zeae EC1]
ATGACAGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGAGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAATCTGAGTGCCACGCTGTCAACCGCACTGGATGCGGAGCTTCGCCGTTATGAGGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGTTTTCATGATGAAAACGGCTGTTTCAGTGATGAATACAGGACCTTTTAA