Detailed information of TA system TA045785

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2797312..2797929
• Replicon: chromosome
• Accession: NZ_CP006929
• Organism: Dickeya zeae EC1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C6CDL0
• Locus tag: W909_RS20265
• Protein ID: WP_012764944.1
• Coordinates: 2797312..2797491 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: W909_RS12305
• Protein ID: WP_016940954.1
• Coordinates: 2797519..2797929 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W909_RS12300	2795198..2797042	+	1845	WP_016940953.1	AAA family ATPase	-
W909_RS20265	2797312..2797491	+	180	WP_012764944.1	type II toxin-antitoxin system HicA family toxin	Toxin
W909_RS12305	2797519..2797929	+	411	WP_016940954.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
W909_RS12310	2798375..2799427	-	1053	WP_016940955.1	phage portal protein	-
W909_RS12315	2799427..2801154	-	1728	WP_016940956.1	terminase family protein	-
W909_RS12320	2801313..2802152	+	840	WP_016940957.1	GPO family capsid scaffolding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6530.61 Da
• Isoelectric Point: 10.7838

>T45785 WP_012764944.1 NZ_CP006929:2797312-2797491 [Dickeya zeae EC1]
MDSRTLIAEIKADGWELVRVNGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Nucleotide

• Length: 180 bp

>T45785 NZ_CP006929:2797312-2797491 [Dickeya zeae EC1]
ATGGACAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAGTTAGTAAGGGTTAACGGCAGTCATCATCATTT
TACCCACCCAACAAAACCGGGATTGGTCACCATCCCACACCCGAAGAAGGATTTACCGATAGGTACGGTAAAAAGCATCA
GGAAACAAGCGGGGATATGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14513.51 Da
• Isoelectric Point: 4.3494

>AT45785 WP_016940954.1 NZ_CP006929:2797519-2797929 [Dickeya zeae EC1]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDEAIANAKEAITGHIELLIEMGQDIPAVSSVGTLAKAPEYTGYTWAV
VDIDVTRLMGGAEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSIR

Nucleotide

• Length: 411 bp

>AT45785 NZ_CP006929:2797519-2797929 [Dickeya zeae EC1]
ATGTTTTATCCAATTGCAATTGAAGCGGGCGACGATACTCATGCATACGGCGTGACAGTGCCGGATCTGCCGGGCTGTTT
CTCCGCAGGTGATACGCTTGATGAGGCCATCGCCAATGCCAAAGAAGCGATCACCGGCCATATTGAGCTGCTGATCGAGA
TGGGCCAGGATATTCCTGCTGTGTCATCCGTCGGAACGCTGGCGAAAGCACCGGAGTACACCGGTTACACCTGGGCTGTT
GTTGATATCGATGTCACCCGGCTGATGGGTGGGGCGGAAAAAATTAACGTCACGTTGCCGAAGTCTCTGATTGACCGTAT
TGACCGCTGCGTAGCGAGTAACCCGGAATTTAAGAGCCGCTCAGGGTTCCTTGCTCAGGCAGCGTTAGAGCGGATTTCAT
CCATTCGCTAA

Structures

Toxin

• AlphaFold DB: A0A2K8W4W9