Detailed information of TA system TA045775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1105043..1105668
• Replicon: chromosome
• Accession: NZ_CP006929
• Organism: Dickeya zeae EC1

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: E0SD87
• Locus tag: W909_RS05125
• Protein ID: WP_009114000.1
• Coordinates: 1105043..1105246 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: W909_RS05130
• Protein ID: WP_016942061.1
• Coordinates: 1105300..1105668 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W909_RS05100	1100667..1101005	+	339	WP_002208627.1	P-II family nitrogen regulator	-
W909_RS05105	1101049..1102341	+	1293	WP_016942065.1	ammonium transporter AmtB	-
W909_RS05110	1102465..1103328	-	864	WP_016942064.1	acyl-CoA thioesterase II	-
W909_RS05115	1103546..1104106	+	561	WP_016942063.1	YbaY family lipoprotein	-
W909_RS05120	1104146..1104472	-	327	WP_016942062.1	MGMT family protein	-
W909_RS05125	1105043..1105246	-	204	WP_009114000.1	hemolysin expression modulator Hha	Toxin
W909_RS05130	1105300..1105668	-	369	WP_016942061.1	Hha toxicity modulator TomB	Antitoxin
W909_RS20010	1106178..1106321	-	144	WP_012770724.1	type B 50S ribosomal protein L36	-
W909_RS05135	1106337..1106588	-	252	WP_029456417.1	type B 50S ribosomal protein L31	-
W909_RS05140	1106760..1109906	-	3147	WP_016942059.1	multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8133.51 Da
• Isoelectric Point: 8.8500

>T45775 WP_009114000.1 NZ_CP006929:c1105246-1105043 [Dickeya zeae EC1]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Nucleotide

• Length: 204 bp

>T45775 NZ_CP006929:c1105246-1105043 [Dickeya zeae EC1]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAACTTTCTAACGACGAACTTGAAATGTTCTATTCAGCTGCCGACCATCGTCTGGCTGAGCTAACGATGAATAAAC
TTTACGACAAAGTGCCAACTGCCGTATGGAAATACGTTCGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14255.15 Da
• Isoelectric Point: 5.6045

>AT45775 WP_016942061.1 NZ_CP006929:c1105668-1105300 [Dickeya zeae EC1]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSRRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Nucleotide

• Length: 369 bp

>AT45775 NZ_CP006929:c1105668-1105300 [Dickeya zeae EC1]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
AACATTAGGTGACAGCCGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGCTGTGTGAGCGGGTTGAAAAATACCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAATGATTCAGAGTTGCAGAAATGGAAAAAATCCAAGTCGCAATT
ATTCAGAATGTTCTCAGAAAAGAGCGTCTGTACGGTAGTAAAAACTTAA

Structures

Toxin

• AlphaFold DB: A0A1X3RNQ0