Detailed information of TA system TA045772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-sanaA/VapC-DUF6088
• Location: 462804..463732
• Replicon: chromosome
• Accession: NZ_CP006929
• Organism: Dickeya zeae EC1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: W909_RS02100
• Protein ID: WP_033576633.1
• Coordinates: 462804..463208 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: W909_RS02105
• Protein ID: WP_016943280.1
• Coordinates: 463289..463732 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W909_RS02085	460119..461024	+	906	WP_016943954.1	hypothetical protein	-
W909_RS02090	461021..462094	+	1074	WP_016943955.1	patatin-like phospholipase family protein	-
W909_RS02095	462574..462804	+	231	WP_033576634.1	antitoxin	-
W909_RS02100	462804..463208	+	405	WP_033576633.1	tRNA(fMet)-specific endonuclease VapC	Toxin
W909_RS02105	463289..463732	+	444	WP_016943280.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
W909_RS02110	463822..464622	+	801	WP_016943279.1	helix-turn-helix transcriptional regulator	-
W909_RS02115	465006..466445	+	1440	WP_016943278.1	sensor domain-containing diguanylate cyclase	-
W909_RS19885	466486..466620	-	135	Protein_412	SAM-dependent methyltransferase	-
W909_RS02120	466905..467759	+	855	WP_016943277.1	pirin family protein	-
W909_RS02125	467956..468294	-	339	WP_029456566.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	445905..471426	25521

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• Protein of unknown function DUF6088 (7-108)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15016.30 Da
• Isoelectric Point: 7.9968

>T45772 WP_033576633.1 NZ_CP006929:462804-463208 [Dickeya zeae EC1]
MLKYLLDTNICIYTIKNKPQEVREAFQRYYGQFAISSITLMELIYGAEKSANPEKNLAVIEGFSARLEIQPYGFDAAVHT
GQIRAELAKKGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWLNP

Nucleotide

• Length: 405 bp

>T45772 NZ_CP006929:462804-463208 [Dickeya zeae EC1]
ATGTTGAAATACCTGCTTGATACCAACATTTGCATTTACACCATAAAGAACAAGCCGCAAGAGGTCAGAGAGGCGTTCCA
GCGTTATTACGGGCAATTTGCGATAAGCTCCATCACGTTGATGGAGCTTATCTATGGCGCGGAAAAGTCGGCCAATCCAG
AAAAGAATCTGGCGGTAATAGAAGGATTTTCCGCACGTCTGGAGATCCAGCCCTATGGGTTTGATGCCGCCGTGCATACC
GGGCAAATCCGTGCCGAGCTGGCAAAAAAGGGAACGCCGATTGGCCCGTATGATGCGATGCTGGCAGGCCATGCGCGCTC
GGCAGGCTTGATACTGGTGACGAACAATGTCCGTGAGTTTGAGCGCGTGCCGGGGCTGCGTGTGGAGAACTGGCTTAACC
CATAG

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16461.01 Da
• Isoelectric Point: 10.8230

>AT45772 WP_016943280.1 NZ_CP006929:463289-463732 [Dickeya zeae EC1]
MTIKTRIQSRLKRSKRYVFTRDDFKDLAGYDQVGRALRELVKEGQLLKVGYGVYTKARKNVITGRLMPASPGGSAAVVIE
ALERLNVPYRFVGATAAYSSGKSTQIPAFLEIEISSRFKRVLTIGNNKLNGRLERFDVGLTVNENDF

Nucleotide

• Length: 444 bp

>AT45772 NZ_CP006929:463289-463732 [Dickeya zeae EC1]
ATGACCATAAAAACGCGTATTCAGTCGCGGCTGAAACGCTCAAAGCGTTATGTATTCACTCGTGACGACTTCAAAGATCT
TGCTGGCTACGATCAAGTTGGCAGGGCGCTGCGTGAATTGGTAAAAGAAGGCCAACTGCTGAAAGTCGGTTATGGCGTCT
ATACCAAAGCGCGGAAAAATGTGATTACGGGTAGGCTAATGCCCGCCTCTCCCGGTGGTTCTGCTGCGGTGGTGATCGAA
GCGCTGGAGCGCTTAAACGTTCCTTATCGTTTCGTTGGTGCAACGGCAGCGTATAGCAGCGGAAAATCTACGCAGATCCC
GGCCTTTCTAGAAATAGAAATCTCATCGCGTTTTAAAAGAGTGTTAACCATCGGCAATAACAAACTCAATGGAAGACTTG
AGCGCTTTGACGTCGGTTTAACTGTTAACGAGAATGACTTTTGA