Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4777978..4778494 Replicon chromosome
Accession NZ_CP006918
Organism Klebsiella pneumoniae 30684/NJST258_2

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KPNJ2_RS24035 Protein ID WP_002886902.1
Coordinates 4777978..4778262 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KPNJ2_RS24040 Protein ID WP_002886901.1
Coordinates 4778252..4778494 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPNJ2_RS24005 4773462..4773770 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
KPNJ2_RS30480 4773855..4774028 + 174 WP_002886906.1 hypothetical protein -
KPNJ2_RS24015 4774031..4774774 + 744 WP_025380808.1 MurR/RpiR family transcriptional regulator -
KPNJ2_RS24025 4775131..4777269 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KPNJ2_RS24030 4777510..4777974 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KPNJ2_RS24035 4777978..4778262 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPNJ2_RS24040 4778252..4778494 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KPNJ2_RS24045 4778572..4780482 - 1911 WP_004152270.1 BglG family transcription antiterminator -
KPNJ2_RS24050 4780505..4781659 - 1155 WP_002886900.1 lactonase family protein -
KPNJ2_RS24055 4781725..4782465 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T45745 WP_002886902.1 NZ_CP006918:c4778262-4777978 [Klebsiella pneumoniae 30684/NJST258_2]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T45745 NZ_CP006918:c4778262-4777978 [Klebsiella pneumoniae 30684/NJST258_2]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT45745 WP_002886901.1 NZ_CP006918:c4778494-4778252 [Klebsiella pneumoniae 30684/NJST258_2]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT45745 NZ_CP006918:c4778494-4778252 [Klebsiella pneumoniae 30684/NJST258_2]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References