Detailed information of TA system TA045727

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhoH-LOG/-
• Location: 849861..852191
• Replicon: chromosome
• Accession: NZ_CP006882
• Organism: Synechococcus sp. WH 8109

Toxin (Protein)

• Gene name: PhoH
• Uniprot ID: -
• Locus tag: Syncc8109_RS04535
• Protein ID: WP_006850748.1
• Coordinates: 849861..851249 (+)
• Length: 463 a.a.

Antitoxin (Protein)

• Gene name: LOG
• Uniprot ID: W0GTG1
• Locus tag: Syncc8109_RS04540
• Protein ID: WP_006849694.1
• Coordinates: 851307..852191 (+)
• Length: 295 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Syncc8109_RS04515	847084..847272	+	189	WP_025362226.1	hypothetical protein	-
Syncc8109_RS12195	847287..847460	-	174	WP_156915486.1	hypothetical protein	-
Syncc8109_RS04520	847733..847993	-	261	WP_006850478.1	hypothetical protein	-
Syncc8109_RS04525	848622..848933	-	312	WP_025362227.1	hypothetical protein	-
Syncc8109_RS04535	849861..851249	+	1389	WP_006850748.1	PhoH family protein	Toxin
Syncc8109_RS04540	851307..852191	+	885	WP_006849694.1	LOG family protein	Antitoxin
Syncc8109_RS04545	852227..852424	+	198	WP_156915487.1	hypothetical protein	-
Syncc8109_RS04550	852481..852657	-	177	WP_006851728.1	hypothetical protein	-
Syncc8109_RS04555	852700..852879	-	180	WP_025362229.1	hypothetical protein	-
Syncc8109_RS04560	853804..854031	-	228	WP_006849935.1	hypothetical protein	-
Syncc8109_RS04565	854229..854414	+	186	WP_025362230.1	hypothetical protein	-
Syncc8109_RS04570	854440..855130	+	691	Protein_919	response regulator transcription factor	-
Syncc8109_RS04575	855225..855458	+	234	WP_025362231.1	hypothetical protein	-
Syncc8109_RS04580	855658..856530	+	873	WP_006850949.1	phycobilisome rod-core linker polypeptide	-
Syncc8109_RS11680	856693..856932	+	240	WP_071823055.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PhoH-like protein (239-453)

Antitoxin

• LOG family (153-281)

Sequences

Toxin

Protein

• Length: 463 a.a.
• Molecular weight: 50913.97 Da
• Isoelectric Point: 5.8023

>T45727 WP_006850748.1 NZ_CP006882:849861-851249 [Synechococcus sp. WH 8109]
MKEKIVVIDTNVLLHDPEAPHRFGDLRVVIPMQVVEEIDRFKKDHSEKGRNARRISRLLDSYRARGSLADGVPIEGTNHG
MLQVVFCQAQALHDLPAELQGGGGDNNILAVALEQMRCSGLKQAPEVLLISKDINLRIKADAVGLQAEDYVNDNVSIDDL
YTGFRELSTDAETIQTLHGEDQLPLEAVADPEVQHLQANEGVVLVDQHNDSHTLLARHQGNTNIIKPLHWLHRAHLGRIK
ARNREQSFALDLLLDPSVALVTLVGKAGTGKTLLAIAAGLHQVADTHHYARLLVTRPPISLGKDIGYLPGTLEEKLGPWM
KPIIDNIDFITGSSPGEEAEQTKKQRHREPRNAWADLQGMGLLEVEAINTIRGRSIPNQFLVVDEAQNLTPLEVKTIVTR
VGEGTKVVFTGDPYQIDNPYVDAESNGLTWLVEKLKGQPLVGHMTLTKGERSELAELAANIL

Nucleotide

• Length: 1389 bp

>T45727 NZ_CP006882:849861-851249 [Synechococcus sp. WH 8109]
ATGAAAGAAAAAATTGTTGTTATCGATACGAATGTGCTGCTACACGATCCTGAGGCGCCGCACCGCTTTGGTGATCTAAG
GGTTGTGATCCCCATGCAAGTGGTTGAAGAAATCGATCGCTTCAAGAAAGATCATTCCGAAAAAGGCCGAAATGCTCGGC
GTATTTCAAGGCTCTTGGATTCCTACCGAGCTCGCGGAAGCCTTGCCGATGGCGTACCGATTGAGGGAACGAACCACGGC
ATGCTGCAGGTGGTGTTCTGTCAGGCCCAAGCCCTCCATGACCTACCGGCAGAGTTGCAGGGGGGCGGTGGTGACAACAA
CATCCTTGCGGTGGCCCTCGAGCAGATGCGTTGCAGTGGCCTGAAACAGGCGCCCGAGGTCCTGCTGATCAGCAAAGACA
TCAACCTGCGAATCAAGGCTGATGCGGTGGGCCTGCAGGCCGAGGACTACGTCAACGACAACGTCTCGATCGACGACCTA
TACACAGGGTTTCGTGAACTCAGTACCGATGCGGAGACAATTCAGACCCTGCATGGCGAGGATCAACTCCCTTTGGAAGC
TGTCGCCGATCCCGAGGTGCAGCATCTTCAGGCCAATGAAGGGGTGGTGCTGGTGGATCAGCACAACGACAGCCACACCC
TGCTTGCTCGGCATCAAGGCAACACCAACATCATCAAGCCGTTGCACTGGCTCCATCGCGCCCATTTGGGACGCATCAAA
GCCAGAAATCGCGAGCAAAGCTTTGCGCTGGATCTGCTGCTCGATCCCTCCGTTGCTCTGGTGACTCTGGTGGGCAAGGC
CGGCACAGGCAAAACGCTGCTGGCCATCGCCGCGGGTTTGCACCAGGTGGCCGACACCCATCACTATGCCCGCTTGTTGG
TGACGCGCCCACCGATCTCCCTTGGCAAAGACATCGGCTACCTGCCCGGCACGCTGGAGGAGAAACTCGGCCCCTGGATG
AAGCCGATCATCGACAACATCGATTTCATCACCGGTTCGTCTCCCGGCGAGGAGGCTGAGCAGACGAAGAAACAGCGGCA
CCGCGAACCACGCAACGCTTGGGCCGACCTGCAAGGCATGGGCTTGCTTGAGGTTGAAGCCATCAACACCATCCGCGGCC
GATCGATTCCCAATCAGTTCCTGGTGGTGGATGAGGCGCAGAACCTGACGCCCCTGGAAGTGAAGACGATCGTGACGCGG
GTGGGTGAAGGAACCAAAGTTGTCTTCACCGGTGATCCATATCAAATCGACAATCCCTATGTGGATGCCGAAAGCAACGG
GCTCACCTGGCTGGTGGAAAAGCTCAAAGGCCAGCCCCTGGTGGGACACATGACCCTCACCAAAGGAGAGCGCAGTGAAC
TGGCTGAACTGGCCGCCAACATCCTCTGA

Antitoxin

Protein

• Length: 295 a.a.
• Molecular weight: 32365.65 Da
• Isoelectric Point: 5.7764

>AT45727 WP_006849694.1 NZ_CP006882:851307-852191 [Synechococcus sp. WH 8109]
MTQFQGTSSPEQTNLDAILKSPTYRIGHEDPDLLNSNAMRGVRMLLEITKPDLQLETAGIESTIIVFGGARIVDKDTAAA
KLAQAEQRLSATPGSSSLKRQVVHAKQLVDLSHFYDAAREFAALASQHGQADKGQSHGCASHVIVTGGGPGIMEAANRGA
FEAGCRSIGLNITLPFEQHPNHFITPDLCFKFNYFSLRKFHFVMRSIGAILFPGGFGTLDELFELLTLRQVGTKGSMPIV
LFGTEFWRRLVDFNYLAEMGLISDDDLDLIHFSDSAEEAWDFIRNRTRAETEAS

Nucleotide

• Length: 885 bp

>AT45727 NZ_CP006882:851307-852191 [Synechococcus sp. WH 8109]
ATGACTCAATTTCAAGGCACTTCAAGCCCTGAGCAAACCAATCTGGATGCGATCCTGAAGTCCCCCACCTACAGAATTGG
CCATGAAGATCCCGACTTGCTGAACAGCAATGCCATGCGCGGTGTGCGCATGCTGCTTGAAATCACCAAGCCGGATCTGC
AACTGGAAACAGCCGGGATCGAATCGACGATCATTGTTTTTGGAGGCGCCAGGATCGTAGATAAAGACACTGCTGCCGCG
AAGCTGGCGCAAGCAGAGCAACGGCTCAGCGCAACTCCAGGCTCATCGTCTTTGAAGAGACAAGTTGTCCACGCCAAACA
GCTCGTGGACTTGTCCCATTTTTACGATGCAGCTCGAGAATTTGCCGCATTGGCCTCCCAGCATGGTCAGGCGGATAAAG
GGCAAAGCCATGGATGCGCATCCCATGTGATCGTGACCGGTGGCGGACCGGGAATCATGGAAGCCGCCAATAGAGGTGCA
TTTGAGGCCGGCTGCCGTTCCATTGGGCTGAATATCACCCTTCCGTTTGAACAACATCCCAATCACTTCATTACCCCTGA
TCTCTGCTTCAAGTTCAACTACTTCTCACTGCGTAAATTCCATTTTGTGATGCGCTCGATTGGAGCCATTCTTTTCCCGG
GCGGCTTTGGCACGCTCGATGAACTGTTTGAGCTGCTCACCCTGCGGCAAGTCGGCACCAAAGGCAGCATGCCCATTGTT
CTGTTCGGAACAGAGTTCTGGAGGAGGCTAGTGGACTTTAATTACCTCGCTGAGATGGGCTTGATTTCAGATGACGACCT
TGATCTGATTCATTTCTCGGATTCAGCGGAAGAGGCATGGGACTTCATCCGCAACCGAACGCGGGCTGAGACTGAGGCGA
GCTGA

Structures

Antitoxin

• AlphaFold DB: W0GTG1